中国药业Issue(18)：41-42,43,3.
调强适形放疗联合西妥昔单抗治疗中晚期鼻咽癌疗效评价
IMRT Combined with Cetuximab in Treating Advanced Nasopharyngeal Carcinoma
符小玲 1蒙漫史 1陈小芬 1李燕霞 1吴伟英1
作者信息
- 1. 海南省海口市人民医院，海南 海口 570208
- 折叠
摘要
Abstract
Objective To observe the efficiency of intensity-modulated radiation therapy (IMRT) combimed with cetuximab in treating advanced nasopharyngeal carcinoma. Methods 40 cases of advanced nasopharyngeal carcinoma were randomly divided into the treatment group and the control group,20 cases in each group. The control group received IMRT plus chemotherapy,meanwhile receiving radiother-apy with cisplatin;on the basis of the control group,the treatment group received cetuximab. The two groups were given comprehensive nursing intervention. The clinical efficiencies of the two groups after the end of treatment were assessed;during treatment,the weekly re-view of blood was conducted,and the periodic examination of the liver and kidney function,blood electrolytes and electrocardiogram (ECG) was conducted biweekly;the adverse reactions related to the treatment was observed. The data of tumor recurrence and death was observed during 3 years of follow-up. Results The total remission rate in the treatment group was 50. 00%,which was higher than 30. 00% in the control group( P ﹤ 0. 05);the CD4+,CD8+,CD4/CD8+ of the two groups had no statistical difference( P ﹥ 0. 05);after 3 years of follow-up,the survival rate of the two groups showed no difference in the first year( P ﹥ 0. 05),the survival rate of the treatment group in the 2,3 years was significantly higher than that of the control group( P ﹤ 0. 05);the incidence rate of adverse reactions such as dermatitis,gastrointestinal and hypersensitivity had no statistical significance( P ﹥ 0. 05),but the oral mucosa reaction in the treatment group was significantly higher than that of the control group( P ﹤ 0. 05). Conclusion The clinical efficacy of IMRT combined with cetuximab in treating advanced nasopharyngeal carcinoma is good,the long-term recurrence rate is low,the adverse re-actions can be controlled,the patients are well tolerated,and appropriate nursing intervention can ensure the smooth progress of the treatment,improve the quality of life of patients,thus is worthy of clinical promotion.关键词
调强适形放射治疗/西妥昔单抗/鼻咽癌/临床疗效/护理Key words
IMRI/cetuximab/nasopharyngeal carcinoma/clinical efficacy/nursing分类
医药卫生引用本文复制引用
符小玲,蒙漫史,陈小芬,李燕霞,吴伟英..调强适形放疗联合西妥昔单抗治疗中晚期鼻咽癌疗效评价[J].中国药业,2015,(18):41-42,43,3.
