摘要
Abstract
ObjectiveTo assess the effectiveness and safety of ozagrel sodium combined with ligustrazine injection in the treatment of acute cerebral infarction (ACI) through Meta analysis.MethodsCochrane library, PubMed, EMbase, Wanfang Data, CNKI and VIP were under computer retrieval combined with manual retrieval. Articles about randomized controlled trails (RCTs) about ozagrel sodium combined with ligustrazine injection in the treatment of ACI were included. Articles were screened and included articles were evaluated through methodology quality. Review Manager 5.2 was used for Meta analysis.Results Totally 15 articles about RCT were included, involving 1519 patients. Results of Meta analysis showed that ozagrel sodium combined with ligustrazine injection could improve clinical efficacy of ACI neurologic impairment with [OR=4.59, 95%CI (3.33, 6.34),P<0.000 01] and [WMD=-3.80, 95%CI (-4.10, -3.49),P<0.000 01]. Conclusion Ozagrel sodium combined with Ligustrazine Injection shows definite clinical efficacy for ACI, without obvious adverse reactions. However, because of the existing low-quality research, more large-scale and multicentric RCTs are required to provide more convinced evidence.关键词
奥扎格雷钠/川芎嗪注射液/急性脑梗死/Meta分析/系统评价Key words
ozagrel sodium/ligustrazine injection/acute cerebral infarction/meta analysis/systematic assessment
