佛山科学技术学院学报（自然科学版）Issue(6)：61-66,6.
N-（4-羟基苯基）-乙酰胺的合成及表征
Synthesis and characterization of N-(4-Hydroxyphenyl)-acetamide
周石洋 1陈玲2
作者信息
- 1. 重庆牧哥食品有限公司，重庆 401520
- 2. 重庆市垫江第二中学，重庆 408318
- 折叠
摘要
Abstract
With 4-Methoxyaniline as raw material, through acetylation,demethylation reactions, the target compound N- (4-Hydroxyphenyl)-acetamide was synthesized and characterized by IR, 1H NMR and 13C NMR. Both in the acetylation reaction, the influence of dosage of catalyst AlCl3, reaction temperature and reaction time on the yield of intermediate N- (4- methoxyphenyl) - acetamide was investigated. In the demethylation reactions, the influence of dosage of catalyst TBAB and bromine hydride, reaction temperature and reaction time on the yield of intermediate N- (4-Hydroxyphenyl)-acetamide was investigated. Under the optimal conditions, the yield of N-(4-Hydroxyphenyl)-acetamide was 94.1% .关键词
4- 甲氧基苯胺/乙酰化/去甲基化/N-(4- 羟基苯基)- 乙酰胺Key words
4-Methoxyaniline/acetylation/demethylation/N-(4-Hydroxyphenyl)-acetamide分类
医药卫生引用本文复制引用
周石洋,陈玲..N-（4-羟基苯基）-乙酰胺的合成及表征[J].佛山科学技术学院学报（自然科学版）,2014,(6):61-66,6.
