广东医学Issue(16)：2491-2494,4.
脑干磁共振病灶特征对脑干临床孤立综合征转归的预测价值
Magnetic resonance imaging feature predicts the conversion in clinically isolated syndrome with pure brainstem lesions
摘要
Abstract
Objective To explore the MRI features of brainstem lesions in clinically isolated syndromes ( CIS) and evaluated their association with clinical conversion .Methods Patients with brainstem CIS were prospectively fol-lowed-up and brain MRI features were retrospectively analyzed .Results A total of 25 patients were followed -up for a median of 65 months.Neuromyelitis optica ( NMO), NMO spectrum disorder ( NMOSD) and multiple sclerosis ( MS) were observed in 5, 4 and 4 cases, respectively.According to MRI,"Fog-like"lesions were significantly more abundant in NMO+NMOSD patients than in MS patients (P=0.001) or stable patients (P<0.000 1).Extensive lesions were on-ly found in 5 (55.6%) patients with NMO+NMOSD.Aqueduct lesions were also significantly more frequently found in NMO+NMOSD patients than in MS patients (P=0.021) or stable patients (P=0.002).The sensitivity and specificity of"Fog-like"lesions in T2 -weight image for diagnosis of NMO +NMOSD were 100% and 93.75%, respectively;while the sensitivity and specificity of extensive lesions for diagnosis of NMO +NMOSD were 55.56%and 100%, respec-tively.The sensitivity and specificity of aqueduct lesions for diagnosis of NMO +NMOSD were 77.78%and 93.75%, re-spectively.Conclusion The "Fog-like", extensive and aqueduct lesions in the brainstem in MRI are important early markers for future NMO and NMOSD .关键词
临床孤立综合征/视神经脊髓炎/多发性硬化/磁共振Key words
MRI/clinically isolated syndrome/neuromyelitis optica引用本文复制引用
杨宁,龙友明,范永祥,单福兰,解龙昌,殷建瑞,蒲蜀湘,高庆春,高聪..脑干磁共振病灶特征对脑干临床孤立综合征转归的预测价值[J].广东医学,2014,(16):2491-2494,4.基金项目
广东省自然科学基金资助项目（编号S2013010016262），广东省科技计划项目 （）
