广西医学Issue(12)：1744-1746,3.DOI:10.11675/j.issn.0253-4304.2014.12.20
GDP与 CHOP方案治疗非特异性外周 T细胞淋巴瘤的疗效分析
Effects of GDP and CHOP Regimens on Treatment of Peripheral T-cell Lymphoma,Unspecified
宋浩 1汪晓虹 1丁凯阳 2耿良权2
作者信息
- 1. 安徽省肿瘤医院暨安徽省立医院西区血液科，合肥市 230031
- 2. 安徽省立医院血液科，合肥市 230001
- 折叠
摘要
Abstract
Objective To investigate the effects of GDP and CHOP regimens on the treatment of peripheral T-cell lymphoma ,unspecified ( PTCL-U) .Methods Sixty-seven patients with PTCL-U were enrolled in the study ,33 cases were treated with the GDP regimen (gemcitabine+cisplatin+prednisone,group GDP),while 34 cases were treated with the CHOP regimen(cyclophosphamide +adriamycin +vincristine +prednisone,group CHOP).The curative effects and adverse reactions were compared between two groups .Results The progression-free survival ( PFS ) and overall survival(OS) of group GDP were higher than those of group CHOP (P<0.05).The total effective rate of group GDP was 72.73%(24/33),while of group CHOP was 47.06%(16/34);The short-term effects of group GDP was better than that of group CHOP(P<0.05).The PFS was (9.5 ±2.9)months and the OS was (15.6 ±6.2)months in group GDP,which were significantly longer than those [(7.3 ±2.2)months and (11.8 ±4.2)months] in group CHOP.The severity of nausea and vomiting in group GDP was lower than that in group CHOP ( P<0 .05 ) , and no statistically significant difference in the other adverse reactions between two groups (P>0.05).Conclusion The curative effect of GDP regimen on the treatment of PTCL-U patients is superior to that of traditional CHOP regimen ,with mild nausea and vomiting .关键词
外周T细胞淋巴瘤/抗肿瘤联合化疗方案/GDP方案/CHOP方案/吉西他滨Key words
Peripheral T-cell lymphoma/Anticancer chemotherapy scheme/GDP regimen/CHOP regimen/Gemcitabine分类
医药卫生引用本文复制引用
宋浩,汪晓虹,丁凯阳,耿良权..GDP与 CHOP方案治疗非特异性外周 T细胞淋巴瘤的疗效分析[J].广西医学,2014,(12):1744-1746,3.
