林产化学与工业Issue(6)：124-128,5.DOI:10.3969/j.issn.0253-2417.2014.06.020
响应面法优化羟基香茅醛1,2-丙二醇缩醛的合成
Optimization of Synthesis of Hydroxyl Citronella Aldehyde-1,2-propanediol Acetal Using Response Surface Method
摘要
Abstract
On the basis of single factor experiments, the synthesis conditions of hydroxyl citronella aldehyde-1,2-propanediol acetal from hydroxycitronellal and 1,2-propylene glycol were optimized using response surface method (RSM). The results of the single factor experiments showed that the most significant factors were the substance ratio of hydroxycitronellal to 1,2-propylene glycol, the reaction temperature and the reaction time. According to the experiment design principle of Central Composite Design, the response surface method of three factors with three levels were employed, and the yield of target compound in the reaction system were taken as the response value to analyze the significance and interaction of the various factors. The optimal synthesis conditions were substance ratio of hydroxycitronellal to 1,2-propylene glycol 1∶3. 5, reaction temperature 38 ℃, reaction time 4. 4 h, and substance ratio of hydroxycitronellal to toluene 1∶2 -1∶2. 5. Under the optimal conditions, the yield of target compound was 89. 76 %.关键词
羟基香茅醛1, 2-丙二醇缩醛/合成/响应面法Key words
hydroxyl citronella aldehyde-1,2-propanediol acetal/synthesis/response surface method分类
化学化工引用本文复制引用
蔡美萍,范国荣,陈尚钘,陈金珠,王宗德..响应面法优化羟基香茅醛1,2-丙二醇缩醛的合成[J].林产化学与工业,2014,(6):124-128,5.基金项目
国家林业公益性行业科研专项经费项目(201304602) （201304602）
江西省主要学科学术和技术带头人培养计划(20133BCB22004) （20133BCB22004）
江西省科技支撑计划项目(20132BBF60057) （20132BBF60057）
