摘要
Abstract
Objective To provide the basis for clinical diagnosis and treatment, investigation and analysis of drug re-sistance during the period of 2009-2014 in elderly patients with ventilator associated pneumonia pathogenic bacteria. Methods Ventilator associated pneumonia, pathogenic bacteria, drug resistance, elderly patients for free word, searching of the Chi-nese journal of full text database were collected during Jan. 2009 and Dec. 2014, and repeatedly published literature and case report were excluded. The literature of clinical data, pathogens and drug resistance were summarized, and summary statistics was performed. Results A total of 23 articles were included with a total of 2595 patients. A total of 4129 strains of pathogens were isolated, including 3149 strains of gram negative bacteria (76. 27% ), 644 strains of gram positive bacteria (15. 60% ), 326 strains of fungi (7. 90% ), 10 strains (0. 24% ) of atypical pathogens; the constituent ratio of top five were: pseudo-monas aeruginosa (23. 93% ), acinetobacter baumannii (19. 28% ), klebsiella pneumoniae (11. 36% ), staphylococcus au-reus (7. 82% ) and stenotrophomonas maltophilia (6. 83% ). Drug resistance analysis showed that gram negative bacteria to ampicillin, cefotaxime sodium, ceftriaxone sodium and ciprofloxacin had obvious resistance, but were sensitive to polymyxin B. Staphylococcus aureus against ampicillin, amoxicillin, cefazolin, imipenem, rifampicin, ciprofloxacin, gentamicin, oxacil-lin sodium and tetracycline were sensitive to vancomycin and linezolid, teicoplanin, quinupristin/ DA Fop Dean showed good sensitivity. Conclusion With widespread use of antibiotics, drug resistance of pathogenic bacteria of VAP increases gradual-ly. Once VAP is suspected, according to empirical initial anti infection treatment, appropriate antimicrobial spectrum should be selected, when the results of pathogenic detection are obtained, the targeted treatment of antibiotics should be readjusted.关键词
肺炎,呼吸机相关性/老年人/抗菌药/病原菌/耐药性Key words
Pneumonia, ventilator-associated/Elderly/Antibiotics/Pathogen/Drug resistance分类
医药卫生
