河南科技大学学报（医学版）Issue(1)：9-13,5.
Rictor在贲门癌组织中的表达及临床意义
Expressions and Clinical Significances of Rictor in Gastric Cardiac Cancer
张鹏飞 1刘永萱 1张亚利 1马志坤 1梁硕 1冯笑山1
作者信息
- 1. 河南科技大学第一附属医院，河南洛阳 471003
- 折叠
摘要
Abstract
Objective To detect the expressions of Rictor in gastric cardiac adenocarcinoma( gCA)and corresponding adjacent normal tissues,analyze the relationship between it and clinical pathological features and prognosis of gastric cardia cancer,judge its possibility as early diagnosis and prognostic index of gastric cardia cancer. Methods The expressions of Rictor in 30 cases of cardiac carcinoma tissues and 30 cases of the corresponding adjacent normal tissues were measured by the fluorescent quantitative PCR method and immunohistochemistry S-P method. Results Rictor gene copy number of adjacent tissues was 9. 10 × 108~11. 12 × 109. gCA was 7. 78 × 105 ~8. 58 × 106. The expression of Rictor protein in the corresponding adjacent normal tissues was 76. 7%(23/30),and the gCA tissue was 56. 7%(17/30). There existed significant difference between them( P < 0. 05 ). There were no significant correlations of the decreased expression of Rictor with the age,sex,TNM and lymph node metastasis(P >0. 05),but tumor differentiation ( P<0. 05). Conclusion The expression levels of Rictor in adjacent tissues is much higher than those in the gCA tissues(P<0. 01). Preliminary inference of the expression of Rictor is related with the progression of cancer,therefore,it may be used in the early diagnosis,therapy and prognosis in gCA.关键词
贲门癌/Rictor/荧光定量PCR/免疫组织化学Key words
carcinoma of gastric cardia/Rictor/quantitative PCR/immunohistochemistry分类
医药卫生引用本文复制引用
张鹏飞,刘永萱,张亚利,马志坤,梁硕,冯笑山..Rictor在贲门癌组织中的表达及临床意义[J].河南科技大学学报（医学版）,2015,(1):9-13,5.
