南华大学学报（自然科学版）Issue(1)：102-107,6.
阿莫西林的γ辐照降解过程与机理试验研究
Studies on γ-irradiation-induced-degradation of Amoxicillin in Aqueous Solution
摘要
Abstract
Amoxicillin was degraded by 60 Co gamma-ray irradiation in aqueous solution. The effects of initial concentration of amoxicillin and absorbed dose on degration of amoxi-cillin were investigated. The identification of radiolytical products has been conducted using high chromatography tandem mass spectrometry and possible pathways for further degration of amoxicillin were studied. Experimental results show that amoxicillin in aqueous solution can be effectively degraded by gammaray irradiation,especially in low-concentration. The amoxicillin degradation rate increased with increasing irradiation dose,whereas the Gvalue decreased,the relationship among amoxicillin removal and absorbed dose can be fit with index curve. Under irradiation dose of 15 kGy, the degration rate reached 100% and 95.14% at amoxicillin of 10 mg/ L,100mg/ L respectively. After irradiation,six major radiolytical products with [M + H] + 278,384,382,336,340,294 were produced,which were detected in several different conditions. Possible pathways for further degration of amoxicillin were studied. Degradation of amoxicillin induced by γ-radiation was mainly ascribed to ·OH oxidation.关键词
γ射线/阿莫西林/辐照降解/LC-MSKey words
gamma-ray irradiation/amoxicillin/degradation/LC-MS分类
资源环境引用本文复制引用
蔡婷,谢水波,吴宇琦,罗志平..阿莫西林的γ辐照降解过程与机理试验研究[J].南华大学学报（自然科学版）,2014,(1):102-107,6.基金项目
国家自然科学基金资助项目(11175081) （11175081）
湖南省高校创新平台基金资助项目(13K085) （13K085）
高等学校博士点基金资助项目(20134324110003) （20134324110003）
