生物信息学Issue(4)：242-248,7.DOI:10.3969/j.issn.1672-5565.2014.04.02
苏太猪ELOVL7基因的生物信息学分析
Bioinformatics analysis of ELOVL7 gene in Sutai pig
摘要
Abstract
Differ to the high similarity between human and mice, the similarity of gene ELOVL7 among pig breeds is low. To uncover this specific character, we analyzed some character of the ELOVL7 gene and its encoding amino acid in Sutai pigs by bioinformatics method, including homology, physical and chemical properties, conserved domains, subcellular localization, signal peptide, transmembrane domain, hydrophilic/hydrophobic, secondary structure, function and kinase-specific phosphorylation site. The results showed that the length of ELOVL7 is 2 324 bp and its 846 bp coding region encodes a protein with 281 amino acids. The structure of ELOVL7 is stable, with 33 387. 4 Da molecular weight, positive charge and basicity. The encoded protein of ELOVL7 gene is a transmembrane, nonsecretory and hydrophobic protein, which most probably is located in cell membrane, containes a conserved domain belonging to GNS1/SUR4 family and has 15 serine, 15 threonine and 20 tyrosine underlying phosphorylated sites. Moreover the similarity of amino acid sequence is over 90% with high homology and its function is mainly involved with transport and binding. The corresponding secondary structure and tertiary structure are primarily composed ofα-helix. Analyzing some characters of the ELOVL7 gene and its amino acid would benefit the study of impaction of potential mutation of ELOVL7 to the syntetic of arachidic acid, and provide insights into the molecular basis of fatty acid metabolism.关键词
ELOVL7/脂肪酸/生物信息学Key words
ELOVL7/Fatty acids/Bioinformatics分类
生物科学引用本文复制引用
章峰,李景,黄路生,张志燕..苏太猪ELOVL7基因的生物信息学分析[J].生物信息学,2014,(4):242-248,7.基金项目
国家自然科学基金(31200926)。 （31200926）
