摘要
Abstract
Objective To study the clinical pathologic characteristics, treatment and prognostic factors of ovarian thecafibroma. Methods From 1986~2011, a total of 168 patients with benign and malignant thecafibroma were retrospectively analyzed. Results The reviewed diagnosis were 16 patients with malignant thecafibroma, 152 patients were benign thecafibroma . Eighteen of 152 patients with benign thecafibroma appeared cel proliferative activity. The mean age was 52years. The most frequent symptoms were abdominal-pelvic onasses (61.9%), metromenor hagia and abnormal vaginal bleeding, other symptoms were abdominal pain, infertility fol owed. fourty-four of 152 patients had ascites, only 2 patients with ascites and hydrothorax sinulaneously. Seventy-eight patients with diseases which associate with excessive extrogenic stimulation, including 2 endometrial adenocarcinoma and 2 endometrial dysplasia and other disease such as : myoma ; endmetial hyperplasia and polyp. One hundred and fifty-two patients with benign thecafibroma were evaluated blood serum CA125 , the CA125 were elevated in 56 of 60 patients . in 4 of 18 patients with cel proliferative activity , the tumors invaded adjacent tissues or relapsed , after received operation and pelvic radiotherapy , they are alive 11years and 27 years respectively .Among 16 patients with malignant thecafibroma , 8 patients without postoperation therapy or with non-standard chemotherapy died in 2 years postoperation , the other 8 patients received operation, postoprational radiotherapy or (and) chemotherapy , 2 of 8 patients died of ir adiation intestinal fistule 4 years later; Four patients are alive without disease more than 10 years , another two for 3 years . Conclusion Thea cel tumor of ovary have good prognosis , but we should pay at ention to thecafibroma with proliferative activity . The prognosis of malignant thecafibroma is poor, postoperative systemic chemotherapy or radiotherapy to the patients with malignant thecafibroma can improve their survival.关键词
卵巢肿瘤/泡膜纤维瘤/病理学/放射疗法/药物疗法/预后Key words
Ovarian neoplasms/Thecafibroma/Prognosis/Radiotherapy/Drug theragy/Pathology
