中国当代儿科杂志Issue(1)：53-57,5.DOI:10.7499/j.issn.1008-8830.2015.01.012
早期不同剂量氨基酸在早产儿静脉营养中的应用价值研究
Value of early application of different doses of amino acids in parenteral nutrition among preterm infants
摘要
Abstract
Objective To study the short-term response and tolerance of different doses of amino acids in parenteral nutrition among preterm infants. Methods This study included 86 preterm infants who had a birth weight between 1 000 to 2 000 g and were admitted to the hospital within 24 hours of birth between March 2013 and June 2014. According to the early application of different doses of amino acids, they were randomized into low-dose group (n=29, 1.0 g/kg per day with an increase of 1.0 g/kg daily and a maximum of 3.5 g/kg per day), medium-dose group (n=28, 2.0 g/kg per day with an increase of 1.0 g/kg daily and a maximum of 3.7 g/kg per day), and high-dose group (n=29, 3.0 g/kg per day with an increase of 0.5-1.0 g/kg daily and a maximum of 4.0 g/kg per day). Other routine parenteral nutrition and enteral nutrition support were also applied. Results The maximum weight loss was lower and the growth rate of head circumference was greater in the high-dose group than in the low-dose group (P<0.05). The infants in the medium-and high-dose groups had faster recovery of birth weight, earlier attainment of 100 kcal/(kg.d) of enteral nutrition, shorter duration of hospital stay, and less hospital cost than those in the low-dose group (P<0.05). Blood urea nitrogen (BUN) levels in the high-dose group increased compared with the other two groups 7 days after birth (P<0.05). The levels of creatinine, pH, bicarbonate, bilirubin, and transaminase and the incidence of complications showed no signiifcant differences between groups (P>0.05). Conclusions Parenteral administration of high-dose amino acids in preterm infants within 24 hours after birth can improve the short-term nutritional status of preterm infants, but there is a transient increase in BUN level.关键词
氨基酸/静脉营养/早产儿Key words
Amino acid/Parenteral nutrition/Preterm infant引用本文复制引用
刘志娟,柳国胜,陈咏鸽,张慧丽,巫雪芬..早期不同剂量氨基酸在早产儿静脉营养中的应用价值研究[J].中国当代儿科杂志,2015,(1):53-57,5.基金项目
广东省科技计划项目（2012B020700006）；清远市科技计划项目（2013B095）。 （）
