中国全科医学Issue(1)：38-40,46,4.DOI:10.3969/j.issn.1007-9572.2015.01.011
糖尿病家族史与高尿酸血症对2型糖尿病发病的协同作用研究
SynergistiC EffeCt between Diabetes Family History and HyperuriCemia on the InCidenCe of Type 2 Diabetes
摘要
Abstract
[AbstraCt] ObjeCtive To explore the synergistic effect of diabetes family history and hyperuricemia on the incidence of type 2 diabetes. Methods In 2009,a stratified random sampling method was used to extract 6 000 community residents from the original 7 districts and 5 cities of Qingdao as the research subjects and eventually 5 165 residents finished investigation with a response rate of 86. 1%. By epidemiological investigation on the spot,791 newly diagnosed type 2 diabetes patients were chosen as the case group,and 4 374 people with normal blood glucose in the control group. An additive model was used to analyze the influence of the interaction between diabetes family history and hyperuricemia on incidence of type 2 diabetes. Results 145 patients(18. 3% )in case group had family history of diabetes and 458 cases in the control group(10. 5% )had family history of diabetes;the difference was statistically significant(χ2 = 40. 10,p < 0. 001). 145(18. 3% )in case group were patients with hyperuricemia and 612( 14. 0% ) in the control group were patients with hyperuricemia;the difference was statistically significant(χ2 = 10. 10,p = 0. 001). Univariate non _ conditional logistic analysis showed that family history of diabetes was the risk factor for type 2 diabetes(OR = 1. 862,p < 0. 001);hyperuricemia was the risk factor(OR = 1. 337,p = 0. 021);when family history and hyperuricemia co _ existing,the risk of type 2 diabetes increased(OR = 2. 885,p < 0. 001)and family history of diabetes and hyperuricemia had a positive interaction on the onset of type 2 diabetes. Multivariate logistic regression analysis showed that when the factor of family history of type 2 diabetes existed alone,OR value was 1. 781 ( p < 0. 001);when hyperuricemia existed alone,OR value was 1. 212(p = 0. 015);when they both existd,OR value was 2. 912(p < 0. 001);family history of diabetes and the incidence of hyperuricemia in type 2 diabetes were still positively interacted. After adjusting confounding factors by multiple logistic regression analysis,the synergy index was 2. 932,the attributable interation was 0. 919, the attributable interaction percent was 31. 56% and the pure attributable interaction percent was 48. 06%. ConClusion Diabetes family history and hyperuricemia had a synergistic effect on the incidence of type 2 diabetes.关键词
糖尿病,2 型/糖尿病家族史/高尿酸血症/协同作用Key words
Diabetes mellitus,type 2/Diabetes family history/Hyperuricemia/Synergistic effect分类
医药卫生引用本文复制引用
刘丽,邵宇涵..糖尿病家族史与高尿酸血症对2型糖尿病发病的协同作用研究[J].中国全科医学,2015,(1):38-40,46,4.基金项目
世界糖尿病基金会项目 （）
