摘要
Abstract
[AbstraCt] ObjeCtive To explore the association between body mass index(BMI),waist to hip ratio(WHR)and esophageal cancer risk in middle aged and elderly people. Methods A hospital _ based case _ control study was conducted. Cases (n = 282)were esophageal cancer patients who were hospitalized in department of oncology and chest surgery,the First Affiliated Hospital and the Third Affiliated Hospital,Liaoning Medical University and Central Hospital,Jinzhou from September,2012 to March,2013 and confirmed by clinical histopathological examination,and controls(n = 282)were patients admitted to the same hospital for different diseases. All of them received face _ to _ face investigation with a standardized questionnaire. Their height and weight,waist circumference and hip circumference were measured and BMI and WHR were calculated. Results There was no statistically significant difference between two groups about age,gender,occupation,education background,and place of residence,as well as the history of hypertension( p > 0. 05 );but the differences in monthly family income per person, drinking,smoking and diabetic history were significant( p < 0. 05). BMI was(24. 43 ± 3. 40) kg/ m2 in case group and (22. 79 ± 3. 30)kg/ m2 in control group;WHR was(0. 96 ± 0. 05)in male cases,(0. 91 ± 0. 05)in male controls,(0. 95± 0. 05)in female cases,and(0. 90 ± 0. 07)in female controls and the differences between the two groups were significant(p< 0. 05). Univariate Logistic regression showed the danger of occurrence of esophageal cancer in case patients whose BMI was 24. 00 ~ 27. 99 kg/ m2 ,≥28. 00 kg/ m2 was 1. 526 times and 1. 817 times respectively that in control patients whose BMI was 18. 50 ~ 23. 99 kg/ m2;the danger in case groups whose WHR was > 0. 95 was 1. 854 times that in control group whose WHR was< 0. 83. After adjusting many confounding factors such as age and gender,etc. ,multiple logistic regression analysis showed that compared with that in the patients in control whose BMI was 18. 50 ~ 23. 99 kg/ m2 ,the danger of the occurrence in case group patients whose BMI was 24. 00 ~ 27. 99 kg/ m2 ,≥28. 00 kg/ m2 was increased by 59. 4% and 78. 2% respectively;compared with that in the patients in control whose WHR was < 0. 83,the danger of the occurrence in case group patients whose WHR was 0. 83 ~ 0. 89,0. 90 ~ 0. 94, > 0. 94 was increased by 4. 8% ,32. 6% and 36. 5% respectively. ConClusion BMI and WHR are important risk factors for esophageal cancer. Overweight or obesity is associated with a significantly increased risk of esophageal cancer. So keeping normal weight may be a protective factor.关键词
食管肿瘤/体质指数/腰臀比/病例对照研究Key words
Esophageal neoplasms/Body mass index/Waist to hip ratio/Case _ control study分类
医药卫生
