中国全科医学Issue(1)：51-54,4.DOI:10.3969/j.issn.1007-9572.2015.01.014
幽门螺杆菌感染对帕金森病患者运动症状的影响研究
InfluenCe of HeliCobaCter Pylori on Motor Symptoms in Patients with Parkinsonˊs Disease
王晏雯 1乔松 1刘小利 1蔡苗 1李雅国1
作者信息
- 1. 310013 浙江省杭州市，浙江医院神经内科
- 折叠
摘要
Abstract
[AbstraCt] ObjeCtive To investigate influence of Helicobacter pylori( Hp)on motor symptoms in patients with Parkinsonˊs disease( PD)and to learn the function of Hp eliminated therapy on the patientsˊ motor fluctuation. Methods Eighty _ nine patients diagnosed with PD from January 2011 to December 2013 in Department of Neurology,Zhejiang Hospital were selected and divided into Hp infection group and Hp noninfection group according to the results of 14 C _ urea breath tests ( 14 C _ UBT). The patients of Hp noninfection group were given Madopar treatment,and Hp eradication therapy was used in Hp infection group besides Madopar. The score of Unified Parkinsonˊs Disease Rating Scale(UPDRS)Ⅲ,the duration of on time and off time and Hoehn _ Yahr staging were used to evaluate the severity of motor symptoms before and after the therapy of Hp eradication. The UPDRS Ⅳ was used to evaluate the change of motor complications before and after treatment. Results The score of UPDRS Ⅳ in Hp infection group was statistically different from that in the group of Hp noninfection(p < 0. 05). Among Hp noninfected patients,the Hoehn _ Yahr stage,the score of UPDRS Ⅲ and UPDRS Ⅳ,the 〞 on _ time〞 and 〞 off _ time〞duration were not significantly different before and after the treatment( p > 0. 05),while they were all significantly different among Hp infection group(p < 0. 05). After the treatment,the difference of 〞 on _ time〞 and 〞 off _ time〞 duration between the two groups(p < 0. 05). ConClusion Hp infection can increase the frequency of motor complications. Hp eradication may improve the motor symptoms and decrease the occurrence of the motor compliance in patients with Parkinsonˊs disease.关键词
帕金森病/运动障碍/幽门螺杆菌Key words
Parkinson disease/Movement disorders/Helicobacter pylori分类
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王晏雯,乔松,刘小利,蔡苗,李雅国..幽门螺杆菌感染对帕金森病患者运动症状的影响研究[J].中国全科医学,2015,(1):51-54,4.
