中国全科医学Issue(1)：105-108,4.DOI:10.3969/j.issn.1007-9572.2015.01.026
小儿推拿疗法在小儿支气管哮喘慢性持续期的作用机制和治疗效果研究
The ACtion MeChanism of Massage on PediatriC Asthma during ChroniC Duration and Its TherapeutiC EffiCaCy
摘要
Abstract
[AbstraCt] ObjeCtive To investigate the therapeutic effect and mechanism of massage on Pediatric asthma during chronic duration. Methods From January,2010 to December,2012,160 asthmatic children according to the diagnostic criteria were recruited from the Affiliated Hospital,Hebei Associated University and the First Affiliated Hospital,Guangzhou Medical University and the Third Peopleˊs Hospital,Wuxi,Jiangsu province and the Affiliated Hospital,Chinese Medicine University of Heilongjiang and were randomly divided into the control group who were treated by conventional atomization and the treatment group who were treated by traditional techniques of pediatric massage and conventional atomization,both for 3 months. Time of attack of asthma,the incidence of respiratory infection,C _ ACT score and maximal expiratory flow(PEF)were recorded both before and after treatment;peripheral venous blood samples were collected to detect the expression intensity of TLR1,TLR2 and TLR4 in Toll _ like receptors,TLR. Results After treatment,compared with those in control group,time of attack of asthma and the incidence of respiratory infection in trial group were lower while C _ ACT score and PEF% were higher,with significant differences(p < 0. 05);the therapeutic efficacy between the two groups was statistically significant( p < 0. 05);the ANG expression levels(ANG fluorescence intensity)of TLR1,TLR2 and TLR4 in macrophagocyte were stronger in trial group than those in control group,with significance( p < 0. 05). ConClusion Massage has a certain clinical effectiveness on pediatric asthma during chronic duration. It may improve the clinical symptoms by up _ regulating the expression level of TLR1,TLR2 and TLR4 in macrophagocyte.关键词
哮喘/小儿推拿/Toll 样受体/作用机制/治疗结果Key words
Asthma/Pediatric tuina/Toll _ like receptors/Active mechanism/Treatment outcome分类
医药卫生引用本文复制引用
田福玲,李旗,崔建美,马树祥,王洪彬,李雪青..小儿推拿疗法在小儿支气管哮喘慢性持续期的作用机制和治疗效果研究[J].中国全科医学,2015,(1):105-108,4.基金项目
国际科技合作计划项目（2013DFG31080）；国家自然科学基金资助项目 （）
