摘要
Abstract
Objective To investigate tbe effects of intravenous preinjection of small dose of lidocaine on tbe effect compartment concen-tration of target controlled infusion of propofol. Methods Totally 80 patients undergoing tracbeal intubation general anestbesia were divided into tbe group A,B,C and D according to tbe random number table,20 cases in eacb group. Before tbe start of anestbesia induction,lidocaine was intravenously injected by 0. 5 mg/kg in tbe group A,1. 0 mg/kg in tbe group B and 1. 5 mg/kg in tbe group C,wbile 0. 9% NaCl was intravenously injected in tbe group D. Tbe cbanges of bemodynamics and propofol effect compartment concen-trations at different time points of before medication(T0),after intravenous injection of lidocaine before anestbesia induction(T1),before tracbeal intubation(T2),after tracbeal intubation(T3),before skin incision(T4),30 min after skin incision surgery(T5)and tbe end of op-eration(T6),after extubation(T7) were observed. Results Tbe values of HR,MAP and SpO2(%) at T0 bad no statistically significant differences among 4 groups( P > 0. 05);tbe detection values of HR and MAP at various time points in 4 groups bad certain fluctuation compared witb tbose at T0,but wbicb in tbe group D was most significant( P < 0. 05);SpO2 at various time points in 4 groups bad no significant cbange( P > 0. 05). Tbe propofol effect compartment concentration in 4 groups bad statistical differences among at T2-T7 ( P < 0. 05),in tbe comparison among 4 groups,group D > group A > group B > group C,tbe differences were statistically significant ( P < 0. 05). Conclusion Intravenous injection of small dose of lidocaine can reduce tbe effect compartment concentration of propofol, and make tbe bemodynamics more satble.关键词
静脉预注/小剂量/利多卡因/丙泊酚/靶控输注/效应室浓度Key words
intravenous preinjection/small dose/lidocaine/propofol/target controlled infusion/effect compartment concentration分类
医药卫生
