中国药业Issue(16)：58-59,60,3.
糖脉康对2型糖尿病患者肠促胰岛素与胰岛素抵抗的影响
Influence of Tangmaikang Granule on GLP-1 and Insulin Resistance in Patients with Type 2 Diabetes
摘要
Abstract
Objective To study tbe influence of Tangmaikang granule on GLP-1 and insulin resistance in newly diagnosed type 2 dia-betic patients. Methods Totally 31 patients were selected and treated by diet,exercise,and Tangmaikang granule(oral,5 g/time,3 times/d). Tbe course of treatment was two weeks,and tbe treatment lasted for two courses. To observe and record tbe MMTT of tbe pa-tients before and after tbe treatment,analyze and evaluate tbe symptoms scores. Tbe blood samples at 0,15,30,60,90,120 min during MMTT were collected,and tbe cbanges of blood glucose,insulin and C-peptide were examined and recorded. Tbe cbanges of blood lipids(TG,LDL-C,TC,HDL-C),bemorbeology and adverse reactions were recorded before and after treatment. Results Compared witb before treatment,tbe clinical symptom score was significantly lower( P < 0. 05 or P < 0. 01);GLP-1 increased at 60 min( P <0. 05),and tbere was no difference at otber time points( P > 0. 05);tbe insulin and C-peptides bad no significant cbange( P >0. 05);tbe glucose levels of blood glucose at 30,60,90,120 min were significantly decreased( P < 0. 05),and tbere were no bypo-glycemia and otber adverse reactions. Conclusion Tangmaikang can granule effectively improve tbe clinical symptoms of tbe newly diag-nosed type 2 diabetic patients,improve insulin resistance and tbe efficiency of insulin,bas no obvious promoting effect on GLP-1. It is safe and deserves to be clinically promoted.关键词
2型糖尿病/糖脉康颗粒/胰岛素/肠促胰岛素Key words
type 2 diabetes/Tangmaikang granule/Insulin/GLP-1分类
医药卫生引用本文复制引用
李忠文,陈重,裴剑浩,李泽,陈红梅..糖脉康对2型糖尿病患者肠促胰岛素与胰岛素抵抗的影响[J].中国药业,2015,(16):58-59,60,3.基金项目
广东省中医药局课题，项目编号2009115；广东省卫生厅课题，项目编号A2010027。 （）
