摘要
Abstract
Objective:To study the expression correlation in miR-126 and protein of vascular endothelial growth factor (VEGF) within lung cancer, and to explore the action mechanisms of miR-126 and lung cancer. Methods:Using tissue microarray platform, miR-126 expressed in lung cancer tis-sues of 56 cases and corresponding paracancerous tissues of 41 cases, and normal lung tissue of 15 cases were examined, applied with situ hybridiza-tion (ISHH);to detect the expression of VEGF protein with western blotting. Results:The positive expression rate of lung cancer with miR-126 was significantly lower than that of paracancerous tissues and normal lung tissues (P<0.05);the expression rate of VEGF protein in lung cancer tissues was significantly higher than that in paracancerous tissues and normal lung tissues (P<0.05). The low expression of miR-126 in lung cancer tissues was closely related with lymphatic metastasis of tumor, where was a certain relationship with the pathological grading. Correlation tests showed that miR-126 and VEGF expression were significantly negative correlation (P<0.05). Conclusion:miR-126 can be used as an important tumor suppressor gene of lung cancer, and potential mark of its metastasis.关键词
肺癌/miR-126/血管内皮生长因子(VEGF)/微小RNA(microRNAs)Key words
miR-126/lung cancer/vascular endothelial growth factor (VEGF)/micro RNA (microRNAs)分类
医药卫生
