北华大学学报（自然科学版）2015，Vol.16Issue(5)：609-612,4.DOI:10.11713/j.issn.1009-4822.2015.05.011
北五味子木脂素抗焦虑作用及机制的研究
On Anti-anxiety Effect and Mechanism of Schisandra chinensis Baill Lignans
摘要
Abstract
Objective To study the anti-anxiety function and mechanism of Schisandra chinensis Baill Lignans ( SCL) . Method Light-dark box test and elevated plus maze test were used to observe the influence of Schisandra chinensis Baill Lignans on mice behaviors administrated intragastrically at low,medium and high dose (35,70 and 140 mg/kg) after 7 days. The blank control group and the positive control group were given normal saline and diazepam(2 mg/kg),respectively. Enzyme-linked immunoabsorbent assay(ELISA) was used for the detection of gamma aminobutyric acid(GABA) in mice serum. Results Light-dark box test and elevated plus maze test results showed that SCL had significant anti-anxiety function at medium and high dose(P<0. 05) with a dose-response relationship. And this kind of anti-anxiety effect could be antagonized by flumazenil. ELISA experiments showed that serum gamma aminobutyric acid ( GABA ) levels of the mice in the medium and high dose group increased significantly. Conclusion Schisandra chinensis Baill Lignans showed significantly anti-anxiety effect,its mechanism may be related with gamma-aminobutyric acid receptor( gamma aminobutyric acid, GABA-R) .关键词
北五味子木脂素/抗焦虑/明暗箱/高架十字迷宫/γ-氨基丁酸Key words
Schisandra chinensis Baill Lignans/anti-anxiety/elevated plus maze/light-dark box/gamma-aminobutyric acid分类
医药卫生引用本文复制引用
刘絮,杜瑞红,于春艳,陈立梅..北五味子木脂素抗焦虑作用及机制的研究[J].北华大学学报（自然科学版）,2015,16(5):609-612,4.基金项目
吉林省教育厅科学技术研究项目(2014209) （2014209）
吉林市科技发展计划项目(201464064). （201464064）
