北华大学学报（自然科学版）2015，Vol.16Issue(5)：627-630,4.DOI:10.11713/j.issn.1009-4822.2015.05.016
氨甲环酸在全髋关节置换术中局部应用的安全性和有效性研究
On Safety and Efficiency of Topical Application of Tranexamic Acid in Total Hip Replacement
摘要
Abstract
Objective To explore the safety and efficiency of topical application of tranexamic acid in unilateral total hip replacement. Method A total of 82 patients who received primary unilateral total hip arthroplasty due to femoral neck fracture were randomly divided into two groups. The patients in the experimental group( group A, n=41 ) were injected 1 . 0 g tranexamic acid within 10 mL normal saline into their articular cavity before suturing the incisions. The control group(group B,n=41) were only injected 10 mL normal saline. The drainage tubes of the patients in the two groups were opened 2 hours later. Then,postoperative blood loss,hidden blood loss,the number of hemoglobin and hematocrit,the number of patients accepted blood transfusion and the blood volume were detected and compared. Clinical symptoms such as pulmonary embolism( PE) and lower extremity deep vein thrombosis(DVT) were also observed. Hemagglutination inspection was operated at the 4th hour before and after the surgery. All above data were recorded and analyzed. Results The amounts of blood loss,hidden blood loss, the number of blood transfusion and blood transfusion volume were much lower,while the values of postoperative hemoglobin and hematocrit were significantly higher in the experimental group compared with those in the control group ( P<0 . 05 ) . There was no significant difference in the results of hemagglutination inspection between the two groups(P>0. 05). And no deep venous thrombosis was observed through doppler ultrasound examination. Conclusion The topical application of tranexamic acid in the aged receiving THA could significantly decrease the amount of blood loss and blood transfusion,which is an efficient and safe way to reduce blood loss.关键词
全髋关节置换术/氨甲环酸/局部应用/失血Key words
total hip replacement/tranexamic acid/topical application/blood loss分类
医药卫生引用本文复制引用
段显亮,孙波,程维,王华..氨甲环酸在全髋关节置换术中局部应用的安全性和有效性研究[J].北华大学学报（自然科学版）,2015,16(5):627-630,4.基金项目
吉林省科技发展计划项目(20130129). （20130129）
