北京大学学报（医学版）Issue(5)：820-824,5.DOI:10.3969/j.issn.1671-167X.2015.05.017
侵袭性牙周炎患者抗伴放线聚集杆菌血清c型IgG滴度分析
Analysis of serum IgG titers to Aggregatibacter actinomycetemcomitans serotype c in aggressive periodontitis patients
冯向辉 1张立 1徐莉 1孟焕新 1陈智滨 1释栋 1路瑞芳1
作者信息
- 1. 北京大学口腔医学院· 口腔医院牙周科，北京 100081
- 折叠
摘要
Abstract
Objective:To analyze the serum IgG titers to Aggregatibacter actinomycetemcomitans ( Aa ) and associated factors in patients with aggressive periodontitis (AgP).Methods:Venous blood samples were collected from 62 AgP patients and 45 periodontal healthy controls , unstimulated whole saliva and pooled subgingival plaque samples of AgP patients were also collected for the detection of Aa ( PCR method) .Serum IgG titers to Aa serotype c were measured by enzyme-linked immunosorbnent assay ( ELISA) .Results:The detection rates of serum IgG to Aa serotype c in the AgP patients and the healthy controls were both 100%.The AgP patients exhibited significantly higher IgG titers to Aa serotype c than the healthy controls (11.1 ±1.9 vs.9.1 ±1.8, P<0.01).There was no significant difference in serum IgG levels to Aa serotype c and in the prevalence of high-responding patients to Aa serotype c between the incisor-first molar type AgP patients and generalized AgP patients .Serum IgG titers to Aa serotype c in the Aa-positive AgP patients ( the patients who were Aa-positive in subgingival plaque or saliva ) were sig-nificantly higher than those of the Aa-negative patients (11.9 ±1.3 vs.10.7 ±2.1, P<0.05).Con-clusion:Serotype c was the main serotype of Aa in Chinese patients with AgP .Serum IgG responses in generalized AgP patients were comparable to those in incisor-first molar type AgP patients .关键词
侵袭性牙周炎/伴放线聚集杆菌/血清组/免疫球蛋白GKey words
Aggressive periodontitis/Aggregatibacter actinomycetemcomitans/Serogroup/Immuno-globulin G分类
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冯向辉,张立,徐莉,孟焕新,陈智滨,释栋,路瑞芳..侵袭性牙周炎患者抗伴放线聚集杆菌血清c型IgG滴度分析[J].北京大学学报（医学版）,2015,(5):820-824,5.
