吉林大学学报（医学版）Issue(6)：1211-1214,4.DOI:10.13481/j.1671-587x.20150622
不同人群乳头瘤病毒 DNA 分型的检测及其临床意义
Detection of human papillomavirus DNA genotypes in different populations and its clinical significance
摘要
Abstract
Objective To analyze the detection results and clinical significance of human papillomavirus (HPV) DNA genotypes in the patients with condyloma acuminate (CA)and high risk (HR)population of CA and normal population of physical examination (PE).Methods 527 cases of CA patients (CA group),208 cases of HR (HR group)and 197 cases of normal PE (PE group)in the outpatient were selected.The human HPV DNA genotypes in 932 samples of different population were examined with HybriMax;the positive detection rates,the preponderance types of HPV and the multiple genotype infection in three groups were analyzed.Results The HPV positive rate in CA group was 98.29% and the preponderance types were HPV 6,11,33,and 52 genotypes.The HPV positive rate in HR group was 26.44% and the preponderance types were HPV 6,11,33,and 66 genotypes.The HPV positive rate in PE group was 5.58% and the preponderance types were HPV 6 and 11 genotypes.The difference in the positive detection rates of HPV between HR and PE groups had statistical significance (P < 0.05 ). The positive rates of multiple genotype infection in CA group and HR group were 36.43% and 5.77%,respectively,and there was significant difference (P < 0.01 ); the positive rate of double infection was the highest (18.41%), followed by the positive rate of triple heavy infection (11.20%) and the positive rate of septuple heavy infection (0.38%).Conclusion The HPV 6 and HPV 11 of low-risk HPV genotypes are the most common genotypes in different population. The HR group and PE group are all asymptomatic but the positive detection rate of HPV in HR group is higher than that in PE group. The positive rate of HPV multiple genotypes infection in CA group is higher than that in HR group,and the double infection or triple heavy infection are the most common infection.关键词
尖锐湿疣/人乳头瘤病毒/基因分型Key words
condyloma acuminata/human papillomavirus/genotype分类
医药卫生引用本文复制引用
刘洋,陈柯霖,李翔燕,李清,李晶华..不同人群乳头瘤病毒 DNA 分型的检测及其临床意义[J].吉林大学学报（医学版）,2015,(6):1211-1214,4.基金项目
国家自然科学基金资助课题 （）
