吉林大学学报（医学版）Issue(6)：1235-1238,4.DOI:10.13481/j.1671-587x.20150626
非小细胞肺癌患者血清叶酸、同型半胱氨酸和维生素 B12的检测及其临床意义
Detection of serum folate,homocysteine and vitamin B12 in patients with non-small cell lung cancer and its clinical significance
摘要
Abstract
Objective To detect the serum levels of folate,homocysteine (Hcy)and vitamin B12 in the patients with non-small cell lung cancer (NSCLC),and to clarify the clinical significance of folate, Hcy and vitamin B12 in the diagnosis and prognosis assessment of NSCLC.Methods 35 patients with NSCLC were chosen as NSCLC group, and 30 healthy people were selected as control group,excluding hypertension,anemia,family disease history and other related factors.The expression levels of serum folate, Hcy and vitamin B12 were examined by circulating enzymatic method and electrochemical luminescence method.The correlations between the levels of serum folate, Hcy and vitamin B12 of the objects in two groups were analyzed by Pearson test.Results The serum Hcy level of the patients in NSCLC group was significantly higher than that in control group (P <0.01).The serum folate level of the patients in NSCLC group was significantly lower than that in control group (P <0.01),while there was no significant difference in vitamin B12 levels between two groups (P > 0.05).The serum Hcy level was negatively correlated with folate level (r=-0.505,P =0.002),but was not correlated with vitamin B12 (r =-0.084,P =0.633).The serum folate level was not correlated with vitamin B12 (r=-0.039,P =0.826).Conclusion The serum Hcy level of NSCLC patient is significantly increased and it has diagnostic and prognostic values in the NSCLC patients.关键词
非小细胞肺癌/叶酸/同型半胱氨酸/维生素 B12Key words
non-small cell lung cancer/folate/homocysteine/vitamin B12分类
医药卫生引用本文复制引用
于秀艳,王文龙,吴雪峰,刘晓峰..非小细胞肺癌患者血清叶酸、同型半胱氨酸和维生素 B12的检测及其临床意义[J].吉林大学学报（医学版）,2015,(6):1235-1238,4.基金项目
国家高技术研究发展计划（863计划）项目资助课题 （）
