磁共振成像Issue(4)：280-285,6.DOI:10.3969/j.issn.1674-8034.2013.04.009
兔VX2肝癌高能聚焦超声治疗后灌注加权成像与微血管密度的比较研究
Comparison of perfusion imaging and microvessel density in rabbit models of hepatic VX2 tumors after high intensity focused ultrasound
摘要
Abstract
Objective: Compare perfusion-weighted imaging (PWI) characteristics and parameters changes with before and after high intensity focused ultrasound (HIFU), supposed to discuss the correlation of Maximal signal reduction slope (SRSmax) and microvessel density (MVD). Materials and Methods:Forty rabbit models of hepatic VX2 tumors were implated successfully, two weeks later, after routine scans were performed on 1.5 T MR scanner, using EPI-SE series, 40 New Zealand white rabbits with VX2 carcinoma were divided randomly into treatment group 20, control group 20, HIFU with treatment group. Perfusion-weighted imaging and enhanced scan were performed 14 d before and after HIFU with both groups. Select the region of interest (ROI) of the central of tumor, surrounding of tumor and paratumor parenchyma. SRSmax of the signal intensity versus time curves were created as quantitative variable. Analyze the SRSmax change degrees and regularities of different ROI. specimens of MVD were examined and compared with PWI. Results: Forty-eight lesions were detected in 40 rabbit models, and 36 lesions in 33 rabbit models were statistical analysis ifnally. Tumor showed heterogeneous were mixed with high signal, normal signal and low signal, the degrees and intensity of blood perfusion in different ROI were different. After HIFU, the SRSmax value of central and surrounding of tumor were statistically decreased than that before HIFU (P<0.05). In control group, the SRSmax value of central of tumor with second were statistically decreased than the first (P<0.05). The SRSmax value of surrounding of tumor in HIFU group were statistically decreased than that of control group (P<0.05). The SRSmax and MVD correlation analysis showed that they were positively correlated with surrounding of tumor in HIFU group (r=0.78, P=0.01). Conclusions:The degrees of blood perfusion of different ROI were consistented with the results of MVD. PWI on VX2 carcinomas are matched with the levels and scopes of necrosis, PWI can be used in evaluating the liver tumor angiogenesis and angioruin with the treatment of HIFU.关键词
癌/肝细胞/超声疗法/磁共振成像/动物,实验Key words
Carcinoma/hepatocellular/Ultrasonic therapy/Magnetic resonance image/Animals, laboratory分类
医药卫生引用本文复制引用
陈亮,魏新华,徐宏刚,刘伟锋,陈立鹏,刘文锋,江新青..兔VX2肝癌高能聚焦超声治疗后灌注加权成像与微血管密度的比较研究[J].磁共振成像,2013,(4):280-285,6.基金项目
广东省科技厅基金项目资助(编号2004B36001043) （编号2004B36001043）
