重庆医学Issue(25)：3488-3490,3.DOI:10.3969/j.issn.1671-8348.2015.25.010
Annexin A1在甲状腺乳头状癌中的表达及临床意义
Expression and clinical significance of annexin A1 in different stages of papillary thyriod carcinoma patients
摘要
Abstract
Objective To explore the correlations between Annexin A1 protein expression and clinicopathological character-istics in carcinoma of papillary thyroid.Methods The different expressions of annexin A1 in papillary thyroid tissue and para-cari-noma tissue were investigated by immunohistochemistry.Results Among 69 samples tissues of papillary thyriod carcinoma,the positive rate of annexin A1 was higher than that of 69 para-carcinoma tissues(88.41%vs .8.69%),there was a significant difference (P <0.05).Furthermore,the expression of annexin A1 was correlation with the lymph node metastasis and tumor size,which was higher in ≥1 cm diameter of tumor(P <0.05).Conclusion High AnnexinA1 positive expression in papillary thyroid cancer tissues is associated with tumor malignant progression,which might be a valuable predictor and potential target for the diagnosis and treat-ment of papillary thyroid carcinoma.关键词
甲状腺乳头状肿瘤/Annexin A1/免疫组织化学Key words
carcinoma of papilly thyroid neoplasms/annexin A1/immunohistochemistry分类
医药卫生引用本文复制引用
钟雪梅,陈敏,邓世山,谢少利..Annexin A1在甲状腺乳头状癌中的表达及临床意义[J].重庆医学,2015,(25):3488-3490,3.基金项目
国家自然科学基金资助项目(81172496)。 （81172496）
