重庆医学Issue(25)：3553-3555,3.DOI:10.3969/j.issn.1671-8348.2015.25.033
PAR2在肝细胞癌组织及其门静脉癌栓中的表达
Expression of PAR2 in portal vein cancer embolus and hepatocellular carcinoma
闪海霞 1范崇桂 1张怀宏1
作者信息
- 1. 河南省南阳市中心医院感染性疾病科 473000
- 折叠
摘要
Abstract
Objective To investigate the expression of proteinase active receptor 2(PAR2)protein in hepatocellular carcino-ma(HCC)and portal vessel tumor thrombosis(PVTT)to evaluate its clinical value.Methods Immunofluorescence,RT-PCR and Western blot were used to examine the expression of PAR2 protein in cancer tissue,tumor thrombosis and cancer-adjacent normal tissue from 21 patients with HCC.Results The expression pattern of PAR2 protein was different cancer tissue and cancer-adjacent normal tissue.PAR2 labeling index was significantly higher in cancer tissue and PVTT than cancer-adjacent normal tissue(P <0.05).Although PAR2 labeling index was lower in cancer tissue than in tumor thrombosis,no statistical significance was observed in PAR2 labeling index between them(P >0.05).Conclusion PAR2 is over-expressed in HCC and PVTT.PAR2 expression is re-lated with the development and progression of HCC.关键词
癌,肝细胞/门静脉癌栓/蛋白酶激活受体2Key words
carcinoma,hepatocellular/portal vessel tumor thrombosis/proteinase activated receptor 2分类
医药卫生引用本文复制引用
闪海霞,范崇桂,张怀宏..PAR2在肝细胞癌组织及其门静脉癌栓中的表达[J].重庆医学,2015,(25):3553-3555,3.
