重庆医学Issue(26)：3631-3633,3.DOI:10.3969/j.issn.1671-8348.2015.26.010
MBD4蛋白在子宫内膜腺癌中的表达及临床意义
Expression of MBD4 protein and its clinical significance in endometrial adenocarcinoma
摘要
Abstract
Objective To study the expression and clinical significance of MBD4 protein in endometrial adenocarcinoma. Methods The MBD4 expression was examined by adopting the SP immunohistochemical method in 45 normal endometrial samples and 60 endometrial adenocarcinoma samples and to analyze its relationship with the clinical staging and pathologic grading.Results The positive expression rate of MBD4 protein in normal endometrium was 60%,which was significantly higher than 25% in endom-etrial adenocarcinoma,indicating the decreasing trend,the difference was statistically significant(P <0.05).The MBD4 protein ex-pression in endometrial adenocarcinoma had no obvious correlation with the clinical staging,pathologic stage,myometrium invasion depth and lymph node metastasis.Conclusion The lack of MBD4 protein in endometrial adenocarcinoma may play a role in the oc-currence and treatment of endometrial adenocarcinoma.关键词
子宫内膜肿瘤/MBD4 蛋白/妇科肿瘤Key words
endometrial adenocarcinoma/MBD4 protein/gynecological tumors分类
医药卫生引用本文复制引用
刘晓丽,史晓雨,程国艳,齐丽宁,宋菲菲,李学慧..MBD4蛋白在子宫内膜腺癌中的表达及临床意义[J].重庆医学,2015,(26):3631-3633,3.基金项目
资助基金:河北省自然科学基金资助项目(H2012206040)。 （H2012206040）
