重庆医学Issue(27)：3768-3771,4.DOI:10.3969/j.issn.1671-8348.2015.27.008
呼吸道肺炎克雷伯菌耐药性与 CTX-M 型 ESBLs 的研究
Study on the resistance of klebsiella pneumoniae which come from respiratory tract and CTX-M ESBLs
摘要
Abstract
Objective To investigate the relationship between the resistance of klebsiella pneumoniae(KP)which come from respiratory tract and CTX-M extended spectrumβ-lactamase(ESBLs).Methods Detecting CTX-M ESBLs genes in the plasmid and chromosomes were used by PCR and sequence analysis;Disk diffusion method was sued by antibiotics susceptibility test;Chi square test was sued by analytic the data.Results CTX-M-1 ESBLs and CTX-M-25 ESBLs were detected in the KP and the total detection rate of CTX-M ESBLs was 39.02%(48 strains),the detection rate of CTX-M-1 ESBLs was 26.02%(32 strains)which existence in the plasmid and chromosomes simultaneously.The resistance rate of β-lactam antibiotic cefazolin,fluoroquinolone antibiotic levo-floxacin and sulfonamides antibiotic bactrim and so on in positive group of CTX-M ESBLs were significantly higher than negative group of CTX-M ESBLs(P <0.05).Conclusion CTX-M-1 ESBLs gene which concurrent in the plasmid and chromosomes may the most common.KP resistance to certain antibiotics closely is relate to the CTX-M ESBLs.关键词
呼吸道感染/肺炎克雷伯菌/超广谱β-内酰胺酶Key words
respiratory tract infections/klebsiella pneumoniae/extended spectrumβ-lactamase分类
医药卫生引用本文复制引用
钟如柱,许志明,喻云梅,刘军,赵祖国..呼吸道肺炎克雷伯菌耐药性与 CTX-M 型 ESBLs 的研究[J].重庆医学,2015,(27):3768-3771,4.基金项目
国家自然科学基金资助项目(81301473) （81301473）
湛江市财政资金科技专项(2013A01007) （2013A01007）
湛江市科技攻关项目(2014BO1184) （2014BO1184）
湛江市科技攻关计划(2012C3106022) （2012C3106022）
广东医学院面上项目(M2012005)。 （M2012005）
