重庆医学Issue(29)：4077-4079,4082,4.DOI:10.3969/j.issn.1671-8348.2015.29.016
1，25-（OH）2D3对哮喘小鼠体内髓系抑制细胞及气道炎症的影响
Effect of 1,25-(OH)2 D3 on the level of MDSCs and airway inflammation in lung of asthmatic mice
陶秋影 1雷瑞瑞 1王亚哲 1韩影 1王祯 1陈茜1
作者信息
- 1. 河南省驻马店市中心医院儿内科 463000
- 折叠
摘要
Abstract
Objective To study the establishment of airway remodeling model ,while the use of 1 ,25‐(OH)2D3 to intervene in the asthmatic mice spleen and peripheral blood myeloid suppressor cells (myeliod‐derived suppressor cells ,MDSCs) level and changes in airway wall thickness were detected .It aims to analyze the 1 ,25‐(OH)2D3 MDSCs and influence on airway inflamma‐tion ,to understand its role in the pathogenesis of asthma .Methods Totally 30 female mice(BALB/c strain) were randomly divided into control group ,asthmatic group and asthmatic1 ,25‐(OH)2D3 group and built asthmatic mouse model .The pulmonary histologi‐cal difference indicative of respiratory tract remodeling among groups were observed via HE staining .The proportion of MDSCs within the peripheral blood and spleen was tested by flow cytometry .Results Typical respiratory tract remodeling were found in asthmatic group with which MDSCs in the peripheral blood and spleen reduced ,asthmatic1 ,25‐(OH)2D3 group comparatively in‐creased ,there had significant difference(P< 0 .05) .Conclusion 1 ,25‐(OH)2D3 may play a role in asthma attacks for a certain treatment ,it may by regulation for MDSCs levels come into play ,so that airway inflammation can be reduced ,at the same time be a‐ble to airway remodeling improvement .关键词
哮喘/小鼠 ,近交BALB C/骨化三醇/髓系抑制细胞MDSCs/气道重塑Key words
asthma/mice ,inbred BALB C/calcitriol/myeliod-derived suppressor cells/airway remodeling分类
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陶秋影,雷瑞瑞,王亚哲,韩影,王祯,陈茜..1，25-（OH）2D3对哮喘小鼠体内髓系抑制细胞及气道炎症的影响[J].重庆医学,2015,(29):4077-4079,4082,4.
