重庆医学Issue(32)：4504-4506,3.DOI:10.3969/j.issn.1671-8348.2015.32.014
223例非小细胞肺癌骨转移发生骨相关事件的临床因素与预后
Clinical factors and prognostic significance of skeletal related events in bone metastasis of non small cell lung cancer in 223 cases
摘要
Abstract
Objective To explore the risk factors of skeletal related events (SREs) in non small cell lung cancer with bone metastases and its effect on the prognosis .Methods Totally 223 cases of NSCLC patients with bone metastasis were retrospective studied from January 2010 to December 2012 in our hospital .The clinical features ,predictive factors for SREs were analysed by sin‐gle factor and multifactor analysis .Results Among 223 cases of NSCLC patients with bone metastasis ,119 cases occured with SREs(53 .4% ) .Univariate analysis showed that the occurrence of SREs in female ,no smoker ,adenocarcinoma ,solitary bone metas‐tasis lesions were less than the male ,smoker non‐adenocarcinoma ,and multiple bone metastases (P<0 .05) ,but the rost without statistically significant(P>0 .05) .The multivariate analysis revealed only multiple bone metastases was an independent risk factor for SREs .The median survival time of the NSCLC patients with bone metastasis was 15 .3 months .Moreover ,survival analysis showed that SREs had no statistical significance on the prognosis of bone metastasis in NSCLC patients (P>0 .05) .Conclusion The female ,adenocarcinoma ,smoking history ,solitary bone metastasis lesions occurred in patients with lower risk SREs .Multiple bone metastasis is an independent risk factor for SREs ,attention should be paid to monitoring and prevention .关键词
癌 ,非小细胞肺/骨转移/骨相关事件Key words
cancer ,non small cell lung/bone metastasis/skeletal related events分类
医药卫生引用本文复制引用
王帅,王东,李钱,卿毅,仲召阳,单锦露,关伟,杨雪琴,王阁,杨镇洲..223例非小细胞肺癌骨转移发生骨相关事件的临床因素与预后[J].重庆医学,2015,(32):4504-4506,3.基金项目
国家自然科学基金资助项目（81171904）；第三军医大学重大临床研究基金（2015001）。 （）
