重庆医学Issue(32):4541-4543,3.DOI:10.3969/j.issn.1671-8348.2015.32.028
甘露醇与甘油果糖联合治疗脑出血的Meta分析
A meta analysis of mannitol combined with glycerin fructose for the treatment of cerebral hemorrhage
摘要
Abstract
Objective To assess whether it have difference between mannitol combined with glycerin fructose and only use mannitol for the treatment of cerebral hemorrhage ,which provides relevant evidence‐based basis for guiding clinical treatment of cerebral hemorrhage .Methods We used literature retrieval through to the China national knowledge internet (CNKI) ,China biolo‐gy medicine disc ,VIP Chinese periodical database ,Wanfang data knowledge service platform and manual retrieval ,and formulate the inclusion and exclusion to screening literature ;and using the Jadad quality evaluation method to evaluate literature which had been included ,heterogeneity inspection at the same time .If the effect of multiple resulted ,we used fixed effect model ;on the other hand , used a random effects model .Results Mannitol combined glycerol fructose significantly improved symptoms and nervous function in patients with cerebral hemorrhage ,and the difference was statistically significant (RR=1 .12 ,95% CI:1 .03 -1 .22 ,P<0 .01);mannitol combined glycerol fructose significantly decreasd impaired renal function and complications (RR=0 .34 ,95% CI:0 .25-0 . 47 ,P<0 .01);mannitol combined glycerol fructose significantly decreasd severe unbalance of electrolyte after taking the medicine (RR=0 .31 ,95% CI:0 .19-0 .49 ,P<0 .01) .Conclusion Compared to use mannitol only ,combination with mannitol and glycerin fructose could effectively improve the prognosis of patients with cerebral hemorrhage ,and reduce the side effects .关键词
甘露醇/脑出血/甘油果糖/M eta分析Key words
mannitol/cerebral hemorrhage/glycerin fructose/Meta-analysis分类
医药卫生引用本文复制引用
高超,黄杰涛,谢延风,石全红..甘露醇与甘油果糖联合治疗脑出血的Meta分析[J].重庆医学,2015,(32):4541-4543,3.基金项目
国家临床重点专科建设项目经费资助(财社[2011]170号)。 ()