吉林医药学院学报Issue(6)：412-415,4.
牛磺酸对镉致小鼠脑组织氧化损伤的保护作用
The protection of taurine on brain tissue oxidative damage induced by cad-mium in mice
摘要
Abstract
Objective To study the protection of taurine on brain tissue oxidative damage in mice exposed to cadmi-um chloride .Methods 40 ICR mice were randomized divided into 4 groups:control group , cadmium-exposed group,two administrated groups .All mouse were evaluated for their learning and memory performance by step-down test.After testing,viscera coefficient,the level of MDA and MAO-B,the activity of SOD were detected.Results The results of step-down test indicated that the wrong number of the cadmium-exposed group was higher than those in the control group and the wrong number of high dose taurine treated group was less than those in the cadmium -exposed group,The difference was statistically significant (P<0.05).The results indicated that viscera coefficient of two ad-ministrated groups was lower than those in the control group ,but there was no statistically significant difference ( P>0 .05 ) .Compared with the cadmium-exposed group ,the MDA levels of high dose taurine treated group were decreased significantly ,The difference was statistically significant ( P<0 .05 ) , while the SOD activities were increased signifi-cantly (P<0.05).Compared with the cadmium-exposed group,the MAO-B levels of control group and two adminis-trated groups decreased significantly (P<0.05),and the MAO-B level in the high dose taurine treated group was low-er than those in the low dose group .Conclusion Taurine has protective effect on brain tissue oxidative damage induced by cadmium in mice .关键词
牛磺酸/氯化镉/氧化损伤/脑组织Key words
ttaurine/cadmium chloride/oxidative damage/brain tissue分类
医药卫生引用本文复制引用
曲莉,白雪松,张晶莹..牛磺酸对镉致小鼠脑组织氧化损伤的保护作用[J].吉林医药学院学报,2015,(6):412-415,4.基金项目
吉林省卫生厅重点实验室资助项目（2010Z056）． （）
