动物医学进展Issue(11)：49-52,4.
白头翁水提物与抗菌药联合对耐药大肠埃希菌作用研究
Study on Effect of Pulsatilla chinensis Water Extract Combined with Antimicrobials against Drug-resistant E.coli
摘要
Abstract
The antibacterial activity of water extract of the Pulsatilla chinensis combining with antibacterial agents was studied against E.coli which both produce fosA3 and ESBLs genes ,it would be as a theoretical basis to treat diseases caused by drug-resistant bacteria.The minimal inhibitory concentration (MIC)of water extract of Pulsatilla chinensis and antibacterial agents were tested through twice micro-dilution method.The drug-resistant E.coli were induced by the 1/2 MIC of water extract of Pulsatilla chinensis combining with antibacterial agents.The result indicated that the MIC of water extract of Pulsatilla chinensis was over 0.5 g/mL.The antibacterial activity of antibacterial agents were strengthened and the MIC of antibacterial agents were reduced significantly when the 0.5 g/mL of water extract of Pulsatilla chinensis combined with thirteen antibacterial agents respectively.Diseases can be treated by water extract of Pulsatilla chinensis combined with antibacterial agents which caused by drug-resistance bacteria.关键词
白头翁/提取物/大肠埃希菌/最小抑菌浓度/耐磷霉素基因/超广谱β-内酰胺酶Key words
Pulsatilla chinensis/extract/E.coli/minimal inhibitory concentration/fosA3/ESBLs分类
农业科技引用本文复制引用
司红彬,唐承明,吴永继,徐素萍,黄丽云,秦燕,姚晓韵,潘婕,黄凯,夏娟..白头翁水提物与抗菌药联合对耐药大肠埃希菌作用研究[J].动物医学进展,2015,(11):49-52,4.基金项目
国家自然科学基金项目（31460675）；国家科技支撑计划（2012BAD25B04）；广西科技攻关项目（0992014-2）；广西自然基金 （）
