广东医学2015，Vol.36Issue(18)：2800-2804,5.
复杂性睡眠呼吸暂停综合征患者临床特征及适应性伺服通气的治疗效果
Clinical characteristics and adaptive servo-ventilation treatment outcomes of complex sleep apnea syndrome.
摘要
Abstract
Objective To observe the characteristics of complex sleep apnea syndrome ( CompSAS) and to evalu-ate the therapeutic outcomes of adaptive servo-ventilation ( ASV) on patients with CompSAS.Methods 303 adult pa-tients underwent continuous positive airway pressure ( CPAP) titration for moderate-severe obstructive sleep apnea-hy-popnea syndrome ( OSAHS) were prospectively studied.Patients were divided into simple OSAHS group and CompSAS group.The CompSAS group was then treated with ASV.Age, gender, weight, BMI, comorbidities were all recorded as well as sleep efficiency, sleep structure, events, lowest oxygen saturation ( LSaO2 ) by polysomnograph ( PSG) for the first night and during CPAP titration and ASV therapy, respectively.Results Nineteen (6.2%) out of the 303 patients under CPAP treatment met the criteria of CompSAS. Prevalence of hypertension ( 73.6%) and congestive heart failure (26.3%) in patients with CompSAS were higher compared to simple OSAHS patients (42.9% and 7%, P<0.05). Central apnea index (CAI) in CompSAS group was increased by CPAP treatment [(9.50 ±2.94)/h] compared to that before CPAP titration [(2.95 ±2.88)/h] (P<0.05).Sleep efficiency, stage Ⅲ sleep proportion and LSaO2 were in-creased with ASV therapy in patients with CompSAS, while AHI and CAI were decreased compared to that with CPAP ti-tration.Conclusion CompSAS patients had higher prevalence of hypertension and congestive heart failure and higher MAI on PSG.Compared with CPAP, ASV therapy may better improve sleep quality, reduce AHI and CAI, and control hypoxemia for patients with CompSAS.关键词
复杂性睡眠呼吸暂停综合征/持续气道正压通气/适应性伺服通气/阻塞性睡眠呼吸暂停低通气综合征Key words
complex sleep apnea syndrome/continuous positive airway pressure/adaptive servo-ventilation/ob-structive sleep apnea-hypopnea syndrome引用本文复制引用
肖冰,何志伟,李浩波,刘园园,钱效森,刘毅..复杂性睡眠呼吸暂停综合征患者临床特征及适应性伺服通气的治疗效果[J].广东医学,2015,36(18):2800-2804,5.基金项目
首都卫生发展科研专项项目(编号:首发2011-6021 -01) （编号:首发2011-6021 -01）
