摘要
Abstract
Objective To explore clinical efficacy of Astragalus injection combined with glucocorticoid in the treatment of lupus nephritis and its effect on immune function of patients.Methods 94 patients with lupus nephritis were divided into combined group (group A, n=47) and control group (group B, n=47) according to the order of treatment.Group B was treated with glucocorticoid, while group A was treated with glucocorticoid and Astragalus injection.Compared the changes of 24 h urinary protein, serum creatinine (SCr), blood urea nitrogen (BUN) and other biochemical indicators before and after treatment of two groups.Recorded the changes of CD3, CD4, CD8 and other immune indices.Results ① After treatment, 24 h urinary protein and BUN of group A were (1.0±0.2)g and (6.1±2.0)mmol/L, significantly lower than (1.9±0.3)g and (8.6±3.4)mmol/L of group B, SCr of group A was (83.4±10.6)μmol/L, significantly higher than (73.1±8.0)μmol/L of group B, with statistically significant differences between two groups (P＜0.05).② There were statistically significant differences in CD3, CD4 before and after treatment in both two groups (P＞0.05);CD8 of group B was (38.9±12.5), significantly higher than (33.6±12.9) of group A, with statistically significant difference between two groups (P＜0.05).Conclusion Astragalus injection combined with glucocorticoid has definite curative effect in the treatment of lupus nephritis, which can improve immune function of patients, worthy of clinical promotion.关键词
黄芪注射液/糖皮质激素/狼疮性肾炎/疗效/免疫功能Key words
Astragalus injection/Glucocorticoid/Lupus nephritis/Efficacy/Immune function
