国际医药卫生导报2015，Vol.21Issue(24)：3629-3631,3.DOI:10.3760/cma.j.issn.1007-1245.2015.24.034
右美托咪定对高血压脑出血开颅血肿清除术的老年患者术后肾功能的影响
Effect of dexmedetomidine on postoperative renal function in elderly patients with hypertensive cerebral hemorrhage undergoing removal of hematoma craniotomy
谢凡 1梁荣耀 1陈玲玲 1杨明明 1聂颖 1李韧韧1
作者信息
- 1. 510000广州,广东三九脑科医院麻醉科
- 折叠
摘要
Abstract
Objective To evaluate the effect of dexmedetomidine on postoperative renal function in elderly patients with hypertensive cerebral hemorrhage undergoing removal of hematoma craniotomy.Methods 60 elderly patients with hypertensive cerebral hemorrhage scheduled for removal of hematoma craniotomy were randomly divided into control group (group C) and dexmedetomidine group (group D) with 30 cases in each group.Anesthesia was induced with target-controlled infusion of remifentanyl and propofol and injection of midazolam,sufentanyl and cisatracurium, endotracheal intubation before mechanical ventilation.Anesthesia was maintained with target-controlled infusion of remifentanyl and propofol and intravenous injection of cisatracurium.In group D,dexmedetomidine 0.2μg/(kg·h) was infused during operation, while the equal volume of normal saline was given instead in group C.The levels of blood urea nitrogen, serum creatinine, urine kidney injury molecule-l (KIM-1) were detected 5 minutes before anesthesia, at the beginning of operation, at the end of operation, postoperative 1 hour, 4 hours, 12 hours and 24 hours (T0-6).Recorded the amount of blood loss, blood transfusion, infusion and urine output.Results BUN and Cr significantly increased at T4, T5, T6 compared with T0 (P＜0.05), KIM-1 significantly increased at T5 and T6 (P＜0.05).BUN, Cr and KIM-1 significantly decreased at T6 compared with T5 (P＜0.05).Compared with group C, BUN and Cr significantly decreased in group D at T4, T5 and T6 (P＜0.05), KIM-1 significantly decreased at T5 and T6.Conclusion Postoperative renal function decreased in elderly patients with hypertensive cerebral hemorrhage undergoing removal ofhematoma craniotomy.Dexmedetomidine play a protective role in renal function of elderly patients with hypertensive cerebral hemorrhage undergoing removal of hematoma craniotomy.关键词
右美托咪定/老年患者/开颅血肿清除术/肾功能Key words
Dexmedetomidine/Elderly patients/Removal of hematoma craniotomy/Renal function引用本文复制引用
谢凡,梁荣耀,陈玲玲,杨明明,聂颖,李韧韧..右美托咪定对高血压脑出血开颅血肿清除术的老年患者术后肾功能的影响[J].国际医药卫生导报,2015,21(24):3629-3631,3.
