甘肃医药2015，Vol.34Issue(9)：641-644,4.
高海拔地区缺氧预处理对大鼠脑缺血再灌注损伤模型脑梗塞体积的影响
The effect of hypoxic preconditioning on the volume of cerebral infarction in the model of infarction/perfusion in Wistar rats in high altitude
摘要
Abstract
Objective:To explore the effect of hypoxic preconditioning on the volume of cerebral infarction in the model of ischemia-reperfusion in adult wistar rats in high altitude. Methods: 60 male adult Wistar rats were randomly divided into hypoxic preconditioning group and control group, 30 rats in each group. In hypoxic preconditioning group, animals were put in hypoxia cabin for 3 hours a day for three days which mimic 5500m altitude, then these rats were fed in Xining city (the altitude of Xining is about 2200m). In control group, rats were fed in Xining normally. Three days after hypoxic preconditioning, these rats were prepared for middle cerebral artery occlusion-reperfusion model. After operation, brain tissue was taken out to undergo TTC staining; the volume of cerebral infarction was calculated and compared. Results: The volume of cerebral infarction was 35.07 ±2.69% in hypoxic preconditioning group, and it was 34.75 ±3.79% in control group. There was no significance difference in the volume of cerebral infarction between the two groups. Conclusion: Hypoxic preconditioning(mimic 5500m altitude, 3 hours a days for 3 days) could not reduce the volume of cerebral infarction in Wistar rats in high altitude.关键词
脑梗塞/缺氧预处理/高海拔/Wistar大鼠Key words
cerebral infarction/hypoxic preconditioning/high altitude/Wistar rat引用本文复制引用
陈晓娟,肖宗宇,潘琪,侯倩,才鼎,周有婷..高海拔地区缺氧预处理对大鼠脑缺血再灌注损伤模型脑梗塞体积的影响[J].甘肃医药,2015,34(9):641-644,4.基金项目
青海省科技创新能力促进计划项目(项目编号:2015-ZJ-943Q)、青海省科技计划项目(项目编号:2012-Z-722) （项目编号:2015-ZJ-943Q）
