摘要
Abstract
Stromal cell derived factor 1 (SDF-1) is only physiological ligand of CXC chemokine receptor 4 (CXCR4). CXCR4 can specifically bind to SDF-1 formed a SDF-1/CXCR4 biological axis, thus completing the corresponding biological effects. SDF-1 and its receptor CXCR4 plays an important role in physiological and pathological processes in the body. A large number of studies show that the roles of SDF-1/CXCR4 in immunity and inflammation, embryo development, activation of anti-apoptotic pathways, hematopoietic stem cell migration, homing, regulation of angiogenesis, hypertensive disorder complicating pregnancy (HDCP), preeclampsia and other biological processes have become a hot spot in biological research. In normal pregnancy, the formed of placenta played a decisive role, so the study on the expression of SDF-1/CXCR4 in the placental bed HDCP will provide a way to explore the possible pathogenesis of HDCP. Bad blood vessel formation process of erosion in trophoblast cells and bad remodeling of the spiral arteries in cell and irregular anti-apoptosis ability exceptions are the key causes of HDCP. Research shows that the decreased of SDF-1/CXCR4 in pregnant women with preeclampsia′s placenta bed has a significant incidence of hypertensive disorder complicating pregnancy. This article reviews SDF-1 and CXCR4′s research progress in hypertensive disorders in pregnancy.关键词
基质细胞衍生因子1/趋化因子,CXC/高血压,妊娠性/先兆子痫Key words
Stromal cell-derived factor 1/Chemokines,CXC/Hypertension,pregnancy-induced/Pre-eclampsia
