国际妇产科学杂志Issue(5)：564-567,4.
PI3K/AKT/mTOR信号通路在卵巢透明细胞癌中的研究进展
Progress in the Research of PI3K/AKT/mTOR Pathway in Ovarian Clear Cell Carcinoma
安闻 1汤小晗 1李萌 1邓锁 1卢美松1
作者信息
- 1. 150001 哈尔滨医科大学附属第一医院妇产科
- 折叠
摘要
Abstract
Ovarian clear cell carcinoma (OCCC) is a special histological subtype of epithelial ovarian cancer, and presents resistant to the traditional chemotherapy on-hand, resulting in poor prognosis, so looking for a novel targeted therapy is extremely urgent. PI3K/AKT/mTOR pathway plays a significant role in the process of occurrence and development of ovarian cancer, and is intimately related to the resistance of chemotherapy. The suppression of apoptosis, the promotion of cell proliferation and the migration of tumor can be enforced by the pathway activation. The various proteins in PI3K/AKT/mTOR pathways express anomaly in the OCCC frequently, and thus the special receptor and kinase of the pathway could be a potential target for the therapy of ovarian clear cell carcinoma. The increasing of paclitaxel or cis-platinum cytotoxic effection and the growth of OCCC are in touch with PI3K/AKT/mTOR pathways in available studies. As the most frequent mutation in OCCC, ARID1A is especially related to PI3K/AKT/mTOR pathways. Therefore, to search for novel targeted drug to the pathway may benefit the treatment of OCCC to some extent. To lay a theory fundation of the new targeted treatment, the relationship of this pathway and OCCC will be interpreted in this paper.关键词
卵巢肿瘤/1-磷脂酰肌醇3-激酶/蛋白激酶类/信号传导/治疗Key words
Ovarian neoplasms/1-phosphatidylinositol 3-kinase/Protein kinases/Signal transduction/Therapy引用本文复制引用
安闻,汤小晗,李萌,邓锁,卢美松..PI3K/AKT/mTOR信号通路在卵巢透明细胞癌中的研究进展[J].国际妇产科学杂志,2015,(5):564-567,4.
