国际妇产科学杂志Issue(5)：568-570,574,4.
卵巢癌纳米靶向药物治疗的研究进展
Research Progress in Drug Delivery Nanoparticles for Ovarian Cancer Treatment
鲍圣芳 1李佳蕊1
作者信息
- 1. 200092 上海交通大学医学院附属新华医院妇科
- 折叠
摘要
Abstract
Ovarian cancer is the leading cause of death among gynecological malignancies. Signs and symptoms of ovarian cancer are frequently absent in early stages. It is easily to invade or spread to other parts of the body. So, it is difficult to diagnose until it spreads and advances to later stages. Some patients cannot tolerate the adverse chemotherapy reaction, so the effect of chemotherapy is hardly satisfactory. Moreover, drug resistance is common and recurrent rate of ovarian cancer is high. These challenges lead to the development of drug delivery nanoparticles for ovarian cancer treatment. Based on enhanced permeability and retention effect, domestic and foreign scholars prepare drug delivery nanoparticles and targeted tumor to complete drug release. It helps to enhance efficacy and reduce side effects in vivo and in vitro research. Various drug delivery nanoparticles are developed by different nanomaterials and some combine with gene, immune therapy. Nano-sized carriers can also be functionalized to both diagnose and treat cancer. This review focuses on different types of targeted nanotherapy for ovarian cancer treatment, including passive targeting, active targeting, magnetic targeting, gene targeting, immune targeting and ultrasound targeting.关键词
卵巢肿瘤/纳米技术/药物载体/基因疗法/药物释放系统Key words
Ovarian neoplasms/Nanotechnology/Drug carriers/Gene therapy/Drug delivery systems引用本文复制引用
鲍圣芳,李佳蕊..卵巢癌纳米靶向药物治疗的研究进展[J].国际妇产科学杂志,2015,(5):568-570,574,4.
