国际妇产科学杂志Issue(5)：583-587,5.
长链非编码RNA在宫颈癌中的研究进展
Research Progress of Long Non-coding RNAs in Cervical Cancer
摘要
Abstract
Long non-coding RNAs (lncRNAs) are a group of RNA molecules which are longer than 200 nucleotides and they cannot encode proteins. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of gene expression network at transcriptional, post-transcriptional and epigenetic levels, which may affect growth, proliferation, differentiation, metabolism, apoptosis and other important physiological processes of cells. In cervical cancer, lncRNA may act as the tumor promoter or tumor suppressor. It is becoming evident that lncRNAs may be an important class of pervasive genes involved in the regulation of multiple cellular biological processes, including apoptosis, tumor invasion and metastasis. lncRNA is hopefully to become the new type of molecular marker and therapeutic target in the diagnosis and treatment of cervical cancer. Combined with domestic and foreign latest reports, there are mainly six lncRNAs may have the role of carcinogenesis: HOX transcription antisense RNA (HOTAIR), lung adenocarcinoma metastasis related transcripts 1 (MALAT1), H19, EBIC, Linc-p21 and brain cell mass (BC200), and mainly two lncRNAs may have the function of cervical cancer suppressor:maternal imprinted genes 3 (MEG3) and XLOC_010588, changing their expression levels of cells may has an obvious effect on the mutiple biological behaviors such as cell proliferation, invasion. Moreover, they are closely associated with clinical pathologic factors of cervical cancer and influence the prognosis of disease.关键词
长链非编码RNA/宫颈肿瘤/基因,肿瘤抑制Key words
Long non-coding RNAs/Uterine cervical neoplasms/Genes,tumor suppressor引用本文复制引用
苏冠男,王冬亮,王武亮,朱前勇..长链非编码RNA在宫颈癌中的研究进展[J].国际妇产科学杂志,2015,(5):583-587,5.基金项目
全军医学科技“十二五”科研项目 （）
