摘要
Abstract
Objective To investigate the pregnancy outcomes of different subtypes of polycystic ovary syndrome ( PCOS) patients after in vitro fertilization and embryo transfer ( IVF-ET) .Methods Retrospective study was conducted among 160 pregnant women with PCOS and 350 infertile women with tubal factors who undergoing IVF-ET.They were divided into four groups:28 cases in obese-PCOS group ( group A) , 132 cases in non-obese PCOS group ( group B) , 41 cases in obese tubal factor group ( group C) , and 309 cases in non-obese tubal factor group (group D) with obesity defined by body mass index (BMI) over 24kg/m2.Clinical characteristics, IVF parameters, pregnancy and perinatal outcomes were analyzed in each group.Results There were significant differences among four groups in age, BMI, proportion of primary infertility, infertility duration and basal FSH level ( t=12.603, P=0.031; t=21.619, P=0.000;χ2 =78.681, P=0.000;t=7.838, P=0.045;t=16.264, P=0.020).The E2 level in hCG day was highest in group B, and the number of retrieved oocytes was also the most, followed by group A, both of which were significantly more than tubal factor groups ( group C and D) ( t=28.581, P=0.000;t=25.492, P=0.000).The fertilization rate, the number of good embryos and the implantation rate of PCOS groups (group A and B) were lower than those of the tubal groups (group C and D), and the differences were significant (t=21.642, P=0.000;t=9.863, P=0.035;χ2 =27.711, P=0.000).The morbidity of GDM and the incidence of large for gestational age infant in obese groups (group A and C) were obviously higher than those in non-obese groups (group B and D) (χ2 =14.698, P=0.002;χ2 =25.003, P=0.000) .The incidence of small for gestational age infant was higher in the PCOS groups ( group A and B) than in the tubal factor groups (group C and D), and the difference was significant (χ2 =8.086, P=0.044).Conclusion There are some differences in IVF parameters, pregnancy and perinatal outcomes between obese and non-obese PCOS patients who undergoing IVF-ET treatment. Compared with non-obese PCOS groups, the number of retrieved oocytes of obese PCOS women is less, and the morbidity of GDM and the incidence of large for gestational age infant increases without influence on clinical pregnancy rate.关键词
多囊卵巢综合征/体外受精-胚胎移植/肥胖/妊娠结局Key words
polycystic ovary syndrome ( PCOS)/in vitro fertilization and embryo transfer ( IVE-ET)/obese/pregnancy outcomes分类
医药卫生
