摘要
Abstract
Objective To study the changes of coagulation indexes in patients with hypertensive disorders complicating pregnancy (HDCP) or gestational diabetes mellitus ( GDM) and make comparison with healthy pregnancy.Methods All pregnant woman were divided into four groups, healthy non-pregnant group (women taking physical examination), healthy pregnant group, HDCP group and GDM group by clinical diagnosis.Prothrombin time ( PT) , activated partial thromboplastin time ( APTT) , antithrombin Ⅲ activity ( AT-Ⅲ) , fibrinogen ( FIB) and D-dimer ( D-D) were measured in four groups.Results Compared with healthy non-pregnant group, healthy pregnant group was not significantly different in APTT, PT, AT-Ⅲ and FIB at 12 and 22 gestational week (all P>0.05), but D-D increased obviously (at 12 gestational week t=15.387,P<0.05;at 22 gestational week t=35.270, P<0.05).And APTT, PT, AT-Ⅲand FIB in healthy pregnant group at 32 gestational week were significantly lower than in the healthy non-pregnant group ( tPT =5.124, tAPTT =6.424,tAT-Ⅲ =5.548, respectively, all P<0.05), but the FIB and D-D were significantly higher (tFIB =58.996, tD-D =19.087, respectively, both P<0.05).The PT, APTT and AT-Ⅲin HDCP group and GDM group were significantly decreased than in the healthy pregnant group (HDCP:tPT =5.402, tAPTT =4.950, tAT-Ⅲ =5.602, respectively, all P<0.05;GDM:tPT =5.069, tAPTT =6.406, tAT-Ⅲ =5.145, respectively, all P<0.05), but the FIB and D-D were significant higher (HDCP:tFIB =5.218, tD-D =5.508, respectively, both P<0.05;GDM:tFIB =6.137, tD-D =4.789, respectively, both P <0.05).The difference in coagulation indexes was not significant between HDCP group and GDM group.Conclusion For HDCP and GDM, detecting coagulation indexes plays an important role in preventing the incidence of DIC.关键词
孕妇/妊娠期高血压疾病/妊娠糖尿病/凝血Key words
pregnant women/hypertensive disorders complicating pregnancy ( HDCP )/gestational diabetes mellitus ( GDM )/coagulation indexes
