医学分子生物学杂志Issue(5)：277-280,4.DOI:10.3870/j.issna.1672-8009.2015.04.007
侵袭性垂体腺瘤患者临床特征与MMP－14、 VEGF表达相关性分析
Association of Clinical Features of Invasive Pituitary Adenoma with Expressions of MMP-14 and VEGF
林大为 1于德安 1李勐 1回鹏1
作者信息
- 1. 抚顺市中医院神经外科 辽宁省抚顺市，113000
- 折叠
摘要
Abstract
Objective To investigate the relationship between clinical features of invasive pitu-itary adenoma and its invasiveness, and between the expression levels of matrix metalloproteinase-14 ( MMP-14) and vascular endothelial growth factor ( VEGF) and the invasiveness of pituitary adeno-mas.Methods A total of 96 patients with pituitary adenoma who were treated between January 2012 and July 2014 in our hospital were examined.There were 46 cases of invasive pituitary adeno-ma and 50 cases of non-invasive pituitary adenoma.The expression levels of MMP-14 and VEGF were immunohistochemically detected, and the association of their expression levels with tumor inva-siveness was analyzed.Results In invasive pituitary adenomas, the strong positive rates of MMP-14 and VEGF were 28.26% and 52.17%, respectively, and the total positive rates were 65.22 %and 95.65 %, respectively, significantly higher than those in non-invasive pituitary adenomas in which the strong positive rates of MMP-14 and VEGF were 14.00% and 20.00%, respectively, and the total positive rates were 42.00% and 56.00%, respectively ( all P<0.05 ) .The maxi-mum diameter and the volume of invasive pituitary adenomas with positive expressions of MMP-14 and VEGF were significantly greater than those of non-invasive pituitary adenomas ( all P<0.05 ) .No significant difference was noted in the maximum diameter and the volume of pituitary adenomas between invasive pituitary adenomas with negative expressions of MMP-14 and VEGF and non-inva-sive pituitary adenomas ( P>0.05 ) .Correlation analysis revealed that the expression of MMP-14was positively associated with that of VEGF in invasive pituitary adenomas (r=0.734, P<0.01). Conclusion The expressions of MMP-14 and VEGF are increased in invasive pituitary adenomas and they can be used as auxiliary biological indicators for the invasiveness of pituitary adenomas.关键词
垂体腺瘤/MMP-14/VEGFKey words
pituitary adenoma/matrix metalloproteinase-14 ( MMP-14 )/vascular endothelial growth factor ( VEGF)分类
医药卫生引用本文复制引用
林大为,于德安,李勐,回鹏..侵袭性垂体腺瘤患者临床特征与MMP－14、 VEGF表达相关性分析[J].医学分子生物学杂志,2015,(5):277-280,4.
