国际口腔医学杂志Issue(1)：76-79,85,5.DOI:10.7518/gjkq.2013.01.020
Toll 样受体介导的细胞内信号通路及其免疫调节功能
Toll-like receptor’s role in intracellular signal pathways and its immune adjustment function
摘要
Abstract
Toll-like receptor(TLR) can trigger intracellular signal transductions and release antimicrobial pro-inflammatory factors, ultimately activating the host immune response by recognizing the evolutionarily conserved structures on pathogens through ligand-binding domain, which contains leucine-rich repeat motifs. The intracellular signal pathways in pulp cells mediated by TLR have important regulatory effects on body immune responses. Thus, this focus review on the expression of TLR in dental pulp tissues, the TLR signal pathways, and the possible great therapeutic implications in curing pulpitis diseases. By doing so, we aim to perfect the theory of pulpitis pathogenesis, and to provide a new angle for developing medical drugs in controlling the pulpitis problems.关键词
Toll样受体/免疫调节/牙髓炎Key words
Toil-like receptor/immune adjustment/pulpitis分类
生物科学引用本文复制引用
洪丽莉,孔倩颖,韦曦..Toll 样受体介导的细胞内信号通路及其免疫调节功能[J].国际口腔医学杂志,2013,(1):76-79,85,5.基金项目
广东省科技计划基金资助项目(2011B050300007) （2011B050300007）
