国际口腔医学杂志Issue(2)：268-272,5.DOI:10.7518/gjkq.2013.02.036
双歧杆菌在肿瘤靶向性基因治疗中的应用
The application prospects of probiotic Bifidobacterium in the tumor targeted therapy
摘要
Abstract
Surgery, chemotherapy and radiotherapy are the conventional cancer treatments. Molecular targeted thera-py is taken as a promising cancer treatment strategy owing to molecular targeted drugs, such as small molecular com-pounds or monoclonal antibodies drugs, with higher efficacy and fewer adverse effects compared with conventional treatments. However, many tumors are very heterogeneous and contain cancer stem cells, which increase the risk of cancer targeted therapy, leading to a lower efficacy cancer treatment. Based on the facts: Hypoxic environment exists in the center of solid tumors, which has previously regarded as a source of resistance to chemotherapy and radiother-apy. Hypoxic area is a common feature in all types of tumors and facilitates anaerobic bacteria to localize in this zone. These provide the rationale for targeted therapy by using a probiotic anaerobic bacterium including Bifidobac-terium. Probiotic Bifidobacterium can locate and growth in the hypoxic area of solid tumors. Therefore, genetic modi-fied Bifidobacterium containing target genes would be used as a very useful tool for cancer treatment, which could make the hypoxic area not be“a forbidden area”. In this review, we will discuss the reason that hypoxic area forms in the solid tumor, the way to use Bifidobacterium as cancer treatment tool, and its related issues including the biosafe-ty, targeted localization, potential application and challenges of genetic modified Bifidobacterium.关键词
实体瘤/分子靶向性治疗/乏氧/双歧杆菌Key words
solid tumor/molecular targeted therapy/hypoxia/Bifidobacterium分类
医药卫生引用本文复制引用
王琳,浦寅飞,王衣祥,郭传瑸..双歧杆菌在肿瘤靶向性基因治疗中的应用[J].国际口腔医学杂志,2013,(2):268-272,5.基金项目
国家自然科学基金资助项目(30872899) （30872899）
