国际口腔医学杂志Issue(4)：429-431,3.DOI:10.7518/gjkq.2013.04.003
人中性粒细胞防御素1~3的日节律性分泌
The circadian rhythm expression of the human neutrophil peptide 1-3
摘要
Abstract
Objective To detect the human neutrophil peptide 1-3(HNP1-3) expression in circadian rhythm. Methods Saliva, peripheral venous blood and gingival crevicular fluid(GCF) samples from mesio-buccal gingival crevice of four first molars of six healthy individuals were collected at two consecutive days from 6∶00 to 22∶00, and the expression of HNP1-3 was detected by enzyme-linked immunosorbent assay(ELISA) method. Results The median in GCF was 5.86μg·L-1, the overall trend was a sinusoidal waveform, with peak at 14∶00 and valley at 20∶00. The median in saliva was 2.15μg·L-1, the overall trend was the “V” word waveform, higher in the morning and evening, the valley at 14∶00. The median in peripheral venous blood was 4.79μg·L-1, the overall trend was single peak waveform, reach-ing a peak from 6∶00 to 10∶00, and then declining slowly. Conclusion The expression HNP1-3 in saliva, GCF, pe-ripheral venous blood samples existed differences. The trend from high to low was GCF, blood, saliva and showed a certain circadian rhythm.关键词
日节律性/人中性粒细胞防御素/龈沟液/外周血液Key words
circadian rhythm/human neutrophil peptide/gingival crevicular fluid/peripheral venous blood分类
医药卫生引用本文复制引用
陈意,陶人川,林雪芳,刘贞敏,雍翔智,李润英..人中性粒细胞防御素1~3的日节律性分泌[J].国际口腔医学杂志,2013,(4):429-431,3.基金项目
国家自然科学基金资助项目 （）
