国际口腔医学杂志Issue(6)：694-698,5.DOI:10.7518/gjkq.2015.06.019
细胞外信号调节激酶信号转导通路在牙发生和再生中的作用
Extracellular signal-regulated kinase signal transduction pathway in dentification and tooth regeneration
班华杰 1王代友2
作者信息
- 1. 广西宜州市人民医院口腔科 宜州546300
- 2. 广西医科大学附属口腔医院口腔颌面外科 南宁530021
- 折叠
摘要
Abstract
Extracellular signal-regulated kinase(ERK) is an important signaling transduction pathway involved in tooth development. The pathway widely regulates dentification and tooth morphogenesis in each developmental stage. Fibroblast growth factor-10 promotes the initiation and development of tooth germ by activating the ERK signaling transduction pathway in dental epithelium. The pathway also regulates the differentiation of mesenchymal stem cells into odontoblasts and the initiation and differentiation of periodontium. Mineral trioxide aggregate can induce odontoblast differentiation by phosphorylating and activating ERK. The pathway is critical in inducing the differentiation of dental pulp stem cell(DPSC) into odontoblasts; hence, activating the ERK signaling pathway in DPSC may be an effective way to regenerate odontoblasts. Hydrostatic pressures during dentification promote mesenchymal osteodifferentiation. By contrast, mechanical stretch inhibits osteogenic differentiation by increasing pERK-mediated cell proliferation. The ERK signaling pathway facilitates the migration of DPSC and the regeneration of dental pulp tissue. This review enumerates the functions of the ERK pathway in dentification and discusses how ERK influences tooth regeneration.关键词
细胞外信号调节激酶/牙发生/牙髓干细胞/牙再生Key words
extracellular signal-regulated kinase/dentification/dental pulp stem cell/tooth regeneration分类
生物科学引用本文复制引用
班华杰,王代友..细胞外信号调节激酶信号转导通路在牙发生和再生中的作用[J].国际口腔医学杂志,2015,(6):694-698,5.
