国际口腔医学杂志Issue(6)：715-719,5.DOI:10.7518/gjkq.2015.06.023
脱落乳牙牙髓干细胞的生物学特性
Biological characteristics of stem cells from human-exfoliated deciduous teeth
谷楠 1孙鑫 1刘富萍 1张宇娜 1张雪 1李海鹰1
作者信息
- 1. 吉林大学口腔医院儿童口腔科 长春130021
- 折叠
摘要
Abstract
Deciduous teeth are constantly exfoliated in the alternate process of deciduous and permanent teeth. Hence, obtaining stem cells from human-exfoliated deciduous teeth(SHED) is simple and convenient. The proliferation rate of SHED was significantly higher than that of dental pulp stem cells and bone marrow mesenchymal stem cells. SHED expressed several growth factors for promoting proliferation, such as fibroblast growth factor, transforming growth factor-β, connective tissue growth factor, nerve growth factor, and bone morphogenetic protein. SHED are able to differentiate into odontoblasts, neural cells, cartilage cells, adipocytes, and liver cells, and can induce host cells to regenerate bone. In addition, SHED have immune modulatory effects and can enhance wound-healing effects. SHED are ideal seed cells for bone and skin tissue engineering. Thus, SHED can potentially be used for treating tooth and bone defects, nervous system diseases, immune system diseases, skin trauma, and liver diseases.关键词
脱落乳牙牙髓干细胞/多向分化/组织再生Key words
stem cell from human exfoliated deciduous teeth/multilineage differentiation/tissue regeneration分类
生物科学引用本文复制引用
谷楠,孙鑫,刘富萍,张宇娜,张雪,李海鹰..脱落乳牙牙髓干细胞的生物学特性[J].国际口腔医学杂志,2015,(6):715-719,5.
